Amitriptyline For Pain Relief

I’ve been taking low dose amitriptyline for over a month now for chronic pain and migraine relief.

Briefly I have had (so far) success with it.  I’m doing a blog post about my experience in the hope it may help others considering trying it.

For me a 20mg dose taken at night has offered excellent day to day relief from migraines, pre-migraine head (feeling light headed and sickly) and for chronic pain like stiffness in my neck and shoulders.

I find with my ME/CFS/CFIDS the low dose is not quite enough to prevent pain and migraine when I do more than usual.  If I overdo it even slightly the pain quickly tips past my blanked out point.  But I find it beneficial all the same and day to day have been using just a fraction of over the counter pain killers and prescribed migraine medication.

I take the amitriptyline at night to avoid the worst of the sedative type effect.  If I have to get up in the night to use the toilet I feel a bit like I am walking through treacle.

I started on a 10mg dose (I think this is the lowest dose you can take).  The relief was just as effective for me as with 20mg but I found it started to wear off around 6-7 hours before the next dose was due (late afternoon and evening for me).  20mg has proven to me the optimum dose for me personally.

I did take my nightly dose up to 30mg under my doctors direction but found the side effects too bad to handle.  I suffered with drowsiness during the day time, constantly feeling like I was ready to sleep.  I also had many headaches and a terrible stiffness in my neck which felt very solid and even worse than the pain I have with no medication at all!  Also I suffered with a constant dry mouth and throat, a sensation not soothed by drinking water or anything else.  The inside of my mouth and back of my throat started to feel like rubber after a week.  I drank lots of fluids (being constantly thirsty) but it didn’t help and just made me need many trips to the toilet!

Now I’m back down to 20mg those effects have gone.  I still feel a little drowsy in the earlier part of the morning but it does not interfere badly with my usual routine.  I also still have a dry mouth but this is only usually very bad 30-60 minutes after taking the tablets.  I also get terrible dry eyes but this is only overnight and does not persist the next day.

The pain relief lasts the whole of the next day up until a couple of hours before my next dose is due.

Everyone is different and people with ME/CFS/CFIDS can be very sensitive to medications.  I have yet to review my findings with my doctor – who knows she may want me to try a bigger dose for longer to see if the side effects persist!

I was highly sceptical about taking a tri-cylic or any kind of anti-depressant for pain relief and was worried it would send out the wrong signals about my condition.  The dosage is too low to have an anti-depressant effect and if people are misinformed I guess it’s up to me to put them straight 🙂 

Although it is still early days on this medication, personally I have found amitriptyline to be a useful  and effective preventative treatment for chronic migraines and pre-migraine feelings, as well as for low level chronic pain.

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UPDATE: 12 August 2010

I’ve been taking amitriptyline for pain relief for over 3 years now.  It is still effective in controlling my day to day pain.  I take my tablets around 7.30pm and taking them earlier has meant I’ve lost that lasting groggy feeling when I wake.

Ten months ago I upped my dosage (with my GP) to 30mg and that is still my current dosage.  I did experience (as before) some initial increase in pain levels when I upped the dose which lasted a few weeks.  I was also a lot more tired in the mornings which may or may not have been related.  It’s very hard to tell with ME/CFS.

It’s difficult to measure if that increase in pain has persisted or not.  Generally speaking I am still not taking as many pain killers or migraine tablets as I was before I had low dose tricyclics.

The side effects of a dry mouth continues to persist but I’m glad to report that I don’t seem to have had any more dental problems than has been typical for me (a sweet tooth I’m afraid).  The thirst and dry mouth bugs me – but the pain relief is worth it.

I do still get pain and migraines.  It’s not totally gone for me.  But day to day the pain is much better.  Also I realise now that my chronic back pain (compacted disc in my lower spine and sciatica) is pretty much gone unless I do silly things to aggreviate the problem.  The pain relief of course masks the pain so I’m still beating up my spine and pinching my nerves but most days I don’t feel it at all.  This is a great bonus for me.

I’m really pleased and proud that so many people have found this blog post useful especially those who’ve felt apprehensive about trying amitriptyline for pain and/or migraine relief.


316 Responses to “Amitriptyline For Pain Relief”

  1. 1 Jacqueline L. Jones July 25, 2007 at 6:03 pm

    Amitriptyline did not work for me. I am very reactive to prescription and most herbal medications. Magnesium and grape seed extract or pine bark extract have worked wonders for my pain.

    I have added your blog to my blogroll. Your candor is helpful for people with chronic pain and fatigue who may not realize that someone else feels the same way.

    • 2 Martha Perry August 17, 2011 at 3:17 pm

      I have read that folks with fibro are more sensitive to all meds and certainly that is true in my case. I do take prescription medications but the lowest dose possible to get some relief. I was a palliative and hospice care nurse, nationally certified in the US for pain management, am now disabled. Lots of great knowledge that helped lots of folks but I have learned that folks with fibro fall way outside the “box” of normal palliative treatment. I have no hesitancy about using prescription, herbals, whatever (safely) and don’t think that everyone needs to use wisely what works for them. And we have to be fluid in our approach as my body changes and what worked yesterday may not be so good for me today and the other way around. Take care out there and do not put yourself in a box by being hesitant to try safely whatever may preserve or enhance quality of life.

  2. 3 Deejay November 15, 2007 at 3:36 am

    I have chronic muscle pain which didn’t respond to analgetics (NSAID). My doctor put me on Amitriptyline (20 mg at night), at the same time started taking Formula 303 (Valerian root, Passionflower and Mg) and the pain is almost gone. I do get some pain in the late afternoon or evening before taking my next dose.

    • 4 April Ashton (OwlLovingApril) April 2, 2012 at 6:26 pm

      I also take Formula 303 as recommended by my chiropractor for sciatica. I started taking Amytriptyline a few weeks ago and have noticed extreme drowsiness. I was prescribed to use it 25mg 3 times a day. I can barely handle one 25mg tablet before bed. I take it about 7:30-9:00 pm and I am ok the next day. It was prescribed for suspected Interstitial Cystitis.

      • 5 Gillian May 17, 2012 at 11:34 am

        That seems quite a lot. I have just been prescribed Amitriptyline for chronic back/muscle and joint pain and have just been given the lowest dose of 10mg ONCE a day (to be taken at night). I would check the dosage just in case. I am going to try Formula 303 as well.

  3. 7 Sara January 19, 2008 at 2:19 am

    I have suffered from chronic pain in my shoulders for about two years now and no one has been able to diagnose the problem. Luckily, one doctor suggested I try 10 mg. of Amitriptyline. I have been on it for almost 2 weeks and I feel tremendously better. I can function well, and my mind is no longer thinking about my aching shoulders. I take it before bedtime and I am also sleeping much better than usual. If I take it too late, (after 10:30 at night) I have a really hard time getting up, so I try to remember to take it earlier in the evening. Around the same time I started to take this medication, I also started exercising and dieting. I have been walking on a treadmill 6 days a week for the last 2 weeks. I started at 1 mile and I am now up to 3 miles. Also, I started to really watch what I eat, as I want to lose 10 lbs. But I haven’t lost any weight at all. I am wondering if anyone else has had weight gain or the inability to lose weight while on such a low dose.

    • 8 leigh November 20, 2010 at 11:52 pm


      • 9 monkey girl March 29, 2012 at 2:21 pm

        i felt the same but it has helped my migraines. i used to get migraines every three days. i still get migraines but no where near as many as before i use this. i have found the pain is less than its. including around that time of month. when i had my period my migraine last three days now it only last about nine hours.

      • 12 Georgie August 24, 2012 at 4:51 pm

        Hi Leigh,
        Thanks for your comment. I wanted to ask you if you had the problem with sleeplessness as well as hunger? I find sometimes I wake up quite often during the night with very vivid dreams.
        Have been taking Amitiriptyline for 3 weeks now and wondered if this side-affect will go away too?
        Many thanks!

      • 13 35nhopeful March 8, 2013 at 9:10 pm

        I now know why I am so hungry…It causes a big difference in my appetite…I also will not wake to anything, not even my alarm next to my head, thats the scary part, i also don’t remember if I do things in the night.

    • 14 Lisa January 22, 2012 at 10:49 pm

      Hi Sara, I’ve been taking Amitriptyline for approximately 3 and half years now and i’m on a low dose 10mg – 20mg. I followed a diet from my doctor (British Heart Foundation) as I was getting married and found I still lost weight following the diet whilst taking the medication for my fibromyalgia. I hope this helps. x

      • 15 Marie pickles May 15, 2012 at 8:07 pm

        Hi Lisa I an really pleased to hear of someone sucessfully losing weight whilst on fibro meds. I have lyrica amytrip morphine patches and flamrase SR. Can u share ur diet as I an extremely overweight and need to tackle this now the pain isnt the topmost thought in my head, hope the wedding was fab x marie

  4. 16 rachelcreative January 19, 2008 at 11:07 am

    Hi Sara. I’ve read that weight gain is very common with amitriptyline but the research is about people on higher doses. But I suppose whatever the reason people gain weight on it could stay be present even a low dose.

    I read that it can effect your blood sugar – maybe that has something to do with it.

    Here’s hoping it’s just a false start to your great efforts for losing a bit of weight.

    If you are concerned or it gets to be a problem talk to your doctor – there are other tricylics that can be prescribed which have good pain relieving effect on a low dose but which have less side effects.

    And thanks for your comment 🙂

  5. 17 ashysheela October 9, 2008 at 5:14 pm

    Went to see my specialist today (primiarily to get a report to support my DLA appeal) but he is suggesting “treatment options” to my doctor for my headaches and head/back/neck/jaw tension/pains, first on the list is amitriptyline so i may be joining you on it soon – it’s reassuring to go back and read your experience… anything to add after being on it so long?

  6. 18 rachelcreative October 9, 2008 at 6:19 pm

    Only that I am still happy taking it :o)

    It makes me very thirsty, it numbs my tongue if I don’t swallow the tablets straight away and the cat seems very interested in it so I have a panic most nights about dropping a tablet and the cat guzzling it down.

    It doesn’t stop all my pain, my aches and my headaches/migraines. It’s like it stops pain andmigraines to a certain level and if I psuh beyond that level it’s like a switch has been flipped and all the pain comes flooding in. BUT I do get that pain relief to a certain level which is good and a lot better than taking tonnes of paracetomal and codeine.

    It doesn’t help my sleep. It does nothing for mood (being a very low dose anyway). But it’s made my migraine medication an average of 6-10 tablets a month instead of that 30 or more I was taking (and still getting migraines) before amitriptyline.

    The most difficult things about it is learning to spell it ;o)

    Oh! I read on forums some people not being able to tolerate it at all. I would say it took me about 6-8 weeks for it to settle fully. I felt like it had settled after 4 weeks but actually it was helping me sleep (making me dozey) up until about 6-8 weeks of taking it.

  7. 19 ashysheela October 9, 2008 at 6:41 pm

    It is hard to spell, i was cutting and pasting it after the search engine said “do you mean ami…”!

    I am hoping it does help with sleep too, but should not get hopes up (as usual!).

    The thirsty thing is a bit worrying as i am always thirsty as it is! My poor bladder is so over-worked…

    I kind of wish they would not always reach to give us pills as the first solution, but i suppose if i am not in pain i will not alter my posture/tense up in reaction to it and that may help ease the problem, whatever the cause is…

    Well, i will see what my doctor thinks (if anything – won’t hold my breath for her to engage with the problem just because the specialist told her to!)…

    Thanks for your feedback – it seems less scary than i had heard in terms of side effects etc. Will just have to see how i tolerate it… i am enough of a zombie as it is so hope i take it well!

    Does your cat like licorice? apparently amitripyline (think that is right!) tastes of it? 😉

  8. 20 rachelcreative October 10, 2008 at 8:07 am

    Can’t say my amitriptyline tastes of licorice. It only makes me thirsty about 20 minutes after I’ve taken it for a while, not for 24 hours. I too am always thirsty (before the meds) drink like a fish and pee like a racehorse ;o)

    I read some really nasty side effects too. It did make me quite woozy and a bit zombie the first week and the first week I upped my dosage. I couldn’t handle 30mg as i was too spaced out so went back to 20mg which is what I am still on now.

    I would say (I forgot this bit) that sometimes I have problems with peeing. Sometimes it’s like retention and sometimes I get sudden urges to wee and have to make a dash for the loo. But it’s not every day and day – it’s time to time and for the large part manageable. The pain relief is kind of worth it.

  9. 21 ashysheela October 10, 2008 at 9:26 am

    ok, well will see how it goes! Think it will take a couple of weeks for the doctor to get the specialist’s recomendations, so won’t be starting right away… thanks for all the info 🙂

  10. 22 Janis October 31, 2008 at 10:59 pm

    Hi Ladies,

    thank you for your info it is interesting. I started experiencing chronic and acute head aches which put me in hospital and the prescription of high doses of codeine and Tramadol and Stematil. This week unhappy about this my GP suggested Amatriptyline. I have been on 10mg for about 8 days and so far so good. Not had a flair up of the Migraine. Sleep is better and leg pain reduced although still a problem in the night. Bladder sensitive as you describe.

    i have also been taking Sinutab for a few days because of pain and heat and inflamed sinus, and I am generally feeling a lot better. If I could bottle todays energy level I could be more hopeful of being able to go back to training.

    Wish you well

    • 23 Kat May 24, 2011 at 12:07 pm

      Firstly thanks so much for this post I have recently been put on Amitriptyline for my sciatica which originally my Doctors had me on Tramadol but sadly I have a high tolerance for a lot of things – i use them and for a while they work but then they don’t stop working so well so either have to up the dose or try something new. Now I’m on 75mg of Amitriptyline a day! (25mg 3 times a day) I’m hoping it will work but so far I have been trying not to take the full amount.

      I also have a friend in Australia who is suffering with chronic pain (neck/shoulders) AND depression so I am going to give him the link to this page and maybe he can talk to his doctors about trying it for his problems too.

      For Janis: Hey Hun just wanted to say I was quite surprised that the Doctors had you on Tramadol for migraines because if you read the literature that comes with it it states something along the lines of not to be taken for headaches as it can make them worse. Personally I found this to be true but it might not happen with everyone. I keep my fingers crossed for you it doesn’t make your migraines worse.

    • 24 Kailin Wylder January 19, 2012 at 4:28 pm

      9 years ago I started using amitriptylene to see if it would help prevent or at least slow down the migraines I was having. I was having them at least twice/week and they were very debilitating. After taking it for a couple of weeks I started seeing a big difference and my migraines slowed down to every couple of months, a couple of times a year, then very seldom and I have not had a migraine now for 5 years. I quit taking it 6 months ago and so far have not had a relapse. It worked well for me and completely changed my life.

      • 25 March 1, 2012 at 12:00 am

        I am on 75mg amitriptylene for over 2yrs now for stiff muscle in back,neck, and head, tention headache,migraine and isomnia. I am feeling a lot better now but I still take the tablets I learn that my pain is cause by my bad posture over the years that cause bad blood circulation to my head. The body bosture exercise help me so much


  11. 26 rachelcreative November 1, 2008 at 9:18 am

    Hello Janis

    Great news that your migraines and pain seem to be responding and (more) under control. Sounds like they were really awful. How wonderful to have some relief! Long may it continue.

  12. 27 LisaV December 8, 2008 at 4:57 pm

    Just to say thank you, I have found your blogs very useful. Ive just been prescribed 10mg amitriptaline for sciatica, and am doing some research before taking my first tablet. I was very poorly on both tramadol and codine (unable to function, urinary retention, vomiting!), but as I am in pain for seven and a half hours a day, I am having to consider other options. I will let you know how I go on. thanks again. LisaV

    • 28 Lorraine September 22, 2010 at 4:54 pm

      Hi Adrian,

      Just read your note on Amitriptyline and Sciatica. I have jus returned from the first visit to the Physio due to Sciatica and partially ruptured disc and they suggested Amitriptyline 10mg.

      I have been on Tramadol and Co-codamol and Diasipam, ll of which I have stopped but the Co-codemol. I have started takng the Amitriptyline tonight and wondered did it help with the Pain as mine is so bad I just cannot wait for some relief x


      Lorraine Green

    • 29 chrissycatcream August 30, 2011 at 4:19 pm

      Hello, out there, Tramadol, made me vomit, sorry to be blunt, I,m now on Amitriptyline, delay finding label to spell it…I was told I had cfs, but now told by another doctor it is fibromyalgia, which mades sensce due to the amount of pain which equal the fatigue, awaiting blood results to be negative, to get treated for this syndrome, been on amitripyline for 1 week however not noticed any improvement yet for pain or sleep problems on 25mg of drug, wonder if there was any thing else to add to the drug herbal or another drug which does not have too many side effect,

  13. 30 Adrian Stowe December 12, 2008 at 9:39 pm


    I take 150mg Amitriptyline for severe headaches and sleep disturbance due to a head injury. I started out on 10 or 20mg but didn’t really get any relief until it was over 100mg.

    It makes me crave carbohydrates after about an hour of taking, it’s pretty uncontrollable, although I’m a bit OCD thanks to the head injury and Ice-Cream is my current obsession. I’ve put on roughly 6 stone since the head injury and at least 3 stone is from the Amitriptyline.

    Really helps with the pain, probably more than the codeine I’m taking.

    When the headaches are really bad only the combination of the Ami, Codeine and Morphine give me any relief. Not every day though thank goodness.

    The dry mouth and throat is horrible, I haven’t found any way to stop that either. Waking up is the worst, mouth and throat are bone dry 🙂

    • 31 chrissycatcream August 30, 2011 at 4:24 pm

      HI adrian, you may snore at night, making your throat and mouth very dry and sore in the mornings, just a thought…….

    • 32 March 1, 2012 at 12:10 am

      I am on 75mg amitriptylene for over 2yrs now for stiff muscle in back,neck, and head, tention headache,migraine and isomnia. I am feeling a lot better now but I still take the tablets I learn that my pain is cause by my bad posture over the years that cause bad blood circulation to my head. The body posture exercise help me so much

      I got real good help from this site


  14. 33 James January 3, 2009 at 11:21 pm

    I LOVE Anitriptyline !!! But I am way past 20mg !! Try 300mg that is only if your Dr. tells you to and your Pain is that bad, and for me it is, It puts you in a haze and it is vary hard to have to work or learn on or Drive or just about do anything but for me it works vary well and life without it is a BITCH. It puts the Pain on a even playing field, it brings it down to a place that you can deal with it. I all so have to take a pain killer with it. But for anyone thinking on taking a higher MG DO NOT DO IT WITH OUT 1ST talking to your DR. because it really slows you down.

    So all and all I think its Great, beats the Hell out of staying in all that Pain.

  15. 34 Tom Anderson January 5, 2009 at 2:06 pm

    Hi There,
    When a diagnosis of M.E/CFS was finally confirmed by a Neurologist 10 years ago ( originally diagnosed by a Chinese accupunturist as P.V.F.S )I was prescribed amytripetc. , but couldn’t tolerate the side effects , my G.P then tried another anti-depressant with the same results.Finally after 5 years tried Citalopram from the smallest dosage and gradually increased the dosage. Been on it since then.
    Omprazole for stomach etc., and thats it for medication.
    I started the Perrin Technique treatment two years ago and have had slow , steady improvement with many symptoms either clearing up or reducing to almost unnoticable..the first to go was the almost continual sore throats.Not walking 100 yards yet.
    My osteopath suggested d-Ribose just before Christmas ,hence reading your blog , so I’m going to give it a go.
    Take it easy,


  16. 35 sachi February 2, 2009 at 12:08 am

    I have been taking Tramadol, Flexaril, Lexapro and not Amitrip… for abour 1 month. I was giving the Amtrip for sleep and relaxation while I sleep. The Lexipro for my Bi-Polar, and the Flexiril for the pain. You would think I would be a Zombie. No in fact I was thinking the Amtrip was no help at all till i read this blog.

    Lexipro 20mg Once a day
    Amtirp 40mg Once a night
    Flexiril 20mg (when needed)

    I know with out my lexipro my family all get flights to other parts of the world till i get back on it.
    But Th Amtrip makes my mouth dry etc. What i had not noticed is that I have not had one Head Ache till today. I for got to take all my meds last night. From what I have read here some of you use it to keep them at bay. I am thinking that is what has kept me Head Pain free for the past month. I will have to go back on it and keep better track.

    Now the other thing i have read is that it is sometimes used to help kids not wet the bed. My 11yr son still has issues with this but also suffers from bad Head aches. I am going to see about getting him on this a.s.a.p.

    I hesitate from calling them migraines though the pain is that bad. My whole family has the same pain in the brain (hehe) as My son and I do. I am looking forward now to talking with his Dr. to see if this may be a key to pain free childhood for him!

    Thanks so much for all the info!

    (ps I cant spell my way out of a paper bag!)

  17. 36 Zissy March 4, 2009 at 5:51 am

    I take it for pain as well but have to cut the pill in half or it makes me loopy for the next two days if I take a full dose. I’ve tried to explain this to my doctor and it’s probably because of the other meds that I take but I’m ignored. So I took it upon myself to cut the pill in half and I’m able to function the next day without pain and stay awake.

  18. 37 Leon March 6, 2009 at 11:16 pm

    My 74 year old father takes Amitriptyline for chronic forehead pain that resulted from nerve damage during retinal surgery over 10 years ago. While it is effective in mitigating the headache pain it has some bothersome side effects. He will experience some minor confusion, forgetfulness and slurred speech. Is this common or likely related to my dad’s age?

  19. 38 rachelcreative March 7, 2009 at 7:22 am

    I found a couple of useful pages which talk about side effects and contra-indidcations for amitriptyline

    Leon this may be of interest:

    “Antidepressants may cause the amount of sodium in the blood to drop – a condition called hyponatraemia. This can cause symptoms such as drowsiness, confusion, muscle twitching or convulsions. Elderly people may be particularly susceptible to this effect. You should consult your doctor if you develop any of these symptoms while taking this medicine so that your blood sodium level can be checked if necessary.”

    Confusion is also listed as a general side effect.

    Best to check with a doctor.

  20. 39 Lochdog April 3, 2009 at 9:03 pm

    Thanks for blogging about this. I’m about to take my first 10mg of ami. Was in a car crash last year and am suffering from back pain 24/7. Had v bad side effects with Tramadol (codeine has no effect) so am going to try ami plus Diclofenac. I’m concerned about taking something which could be addictive, but chronic pain is affecting my life so much that needs must. I’ve heard about the dry mouth and would be interested to know what works best for folks, esp as a few have said that drinking doesn’t help.

  21. 41 rachelcreative April 4, 2009 at 4:29 pm

    I’m not aware that amitriptyline is addictive though codeine can be.

    Sorry to hear about your pain. Hope the medication can help. Chronic pain is so wearing.

    If you find any answers about dry mouth please let me know! I haven’t found a trick. Drinking doesn’t really get rid of the dry mouth thing.

    I read something recently about “artificial saliva”. Sounds horrible! I knew you could get artificial tears as eye drops but haven’t heard of artificial saliva before!

    I thought I might ask my dentist (if I can remember) for any advice next time I see her. A dry mouth can add to the risk of tooth decay apparently as you’re lacking saliva as a natural defence. As if we need that too!

    Off to search the web for artificial saliva 😉

    • 42 Heather Whitehead March 16, 2017 at 9:48 pm

      I’m just about to take a 10mg Amitriptyline given to me by my gp today for persistent pain in both grions. In the past I;ve had pregabalin etc and ended up with dry mouth syndrome and was given saliva pastilles by my gp…good luck.

  22. 44 ashysheela April 5, 2009 at 9:34 am

    i was on antidepressants for a while and while not really aware of my dry mouth most of the time, it did reduce my saliva and this lead to me having several fillings at my 6 monthly check up – a rate of tooth decay that was truly shocking. My dentist suggested a good mouth wash, though another said not to put “that stuff” anywhere near your mouth and to use saline, which i found quite unpleasant, but i believe both will help to prevent tooth decay.

  23. 45 rachelcreative April 5, 2009 at 11:11 am

    I also read that when you brush your teeth at night not to rinse your mouth out with water but just to spit. It might help to prevent tooth decay but it doesn’t do much for that dry mouth sensation (if anything it adds to it!).

  24. 46 ashysheela April 5, 2009 at 5:53 pm

    i read that too, but am not keen on minty chalky mouth all night!

  25. 47 Pat Bailey May 20, 2009 at 10:29 am

    I have been on Amitripyline now for a few weeks now and yes it makes you feel groggy the next day . I feel it does help me sleep better but the dry mouth and numb tongue and tingling lips are a bit concerning . I am determined to carry on with it for a while. When I first got the swollen tonge and tingling lips it made me look like I had had a stroke. !!!

    • 48 rachelcreative May 21, 2009 at 7:49 am

      Pat – what has helped me with the morning groggy feeling is to take the amitriptyline earlier in the evening. Take it about 10-12 hours before you want to wake. I’m so grateful another ME person gave me that tip – it has really helped.

  26. 49 Therese Colligan May 27, 2009 at 11:58 am

    I too am taking this drug, which has helped quite a bit, but my mornings are still very difficult. I feel like I’ve traded one evil for another some days. Any suggestions regarding difficulty waking up? I only take 10 mg.

    • 50 rachelcreative May 28, 2009 at 10:05 am

      Therese – as I said to Pat above … what has helped me with the morning groggy feeling is to take the amitriptyline earlier in the evening. Take it about 10-12 hours before you want to wake.

  27. 51 -T June 10, 2009 at 12:41 am

    I’ve been on amitriptyline for about 2 weeks and my headaches/migranes have pretty much disappeared. Its really kind of weird not to have a headache looming day in and day out. I’ve had them since I was a kid and I’m in my 30’s now. I was running out of OTC pain meds that would work on me. But now I rarely have to take anything for headaches. I feel quite lucky to have found this stuff. I take it during the day because if I take it at night, I have a hard time waking up. But I’ll take the groggyness over a migrane anyday!!

  28. 52 dr2becynthia June 10, 2009 at 4:46 am

    It was interesting to read all the comments regaarding the use amitriptyline for chronic pain. I am on my second round of treatment for chronic pain in my lower jaw, and my pain management doctor prescribed amitriptyline, and needless to say , I was a little skeptical. However, the pain is not so bad, and certainly not as severe. I’ve actually had some very good days. The first round consisted of Xanax, and I was still in pain. Side effects…dry mouth, yes!!! Weight gain…yes, but I know I just need to watch what I eat and exercise more.I will consider taking it earlier in the evening to avoid the sleepiness the next day. Thanks for sharing.

  29. 53 sheila July 1, 2009 at 1:41 pm

    Hi Folks

    I have been suffering from neck pain resulting from whiplash injury
    3 years ago. Also feel so tired all the time without refreshing sleep. My Doc. has put me on 10mg of amitriptiline and I am hoping
    that this will help me get better sleep. I am 74 but want to feel 47 again!!! I am in a singing group where we have to perform choreography and I don’t want to have to give up yet!
    Doc has put me on Amitriptiline 10mgs at night. I will keep you posted of improvement.

    Somerset UK

  30. 54 The Mazster July 1, 2009 at 8:22 pm

    i’d say amitriptyline is addictive. I’ve been on them for 12 yrs and can’t get off them – when i have tried i get bad effects like no sleep (and i mean NO sleep), feel sick, feel downright awful. I was on 150mg but down to 30 but thats as low as i can go without effects. I get headaches every day but i’d sonner that than no sleep. awful pills! Hate them.

  31. 55 Michael July 12, 2009 at 4:39 pm

    Been reading through the blogs and questions posed in them. I have taken it for three years at 20 mg per day at night. Mine was prescribed for migraine vertigo? Or at least that is what the MD called it. I get dizzy and fall if standing, completely wipes me out for two to three hours. It helped with the frequency of attacks.

    I am now on 50 mg for help with depression. Haven’t seen help with the pain side of the increased dosage, but it may be a pain over the threshold of what that dosage blocks.

    As far as other side effects such as dry mouth or beeing drowsy I take it at night so haven’t seen or felt that.

    Oh yeah, artificial saliva is available, my mother used it for years while battling cancer.

  32. 56 sophia September 16, 2009 at 3:48 am

    I suffer from arnold chiari malformation (herniated cerebellum) and suffer severe head and neck pain everyday for the last eight years my nuerologist recommends I take amitripyline 10mg. I got the prescription today should I be worried I have a 9 year son to care for but desperately need relief. Is this medicine going to affect me as a mom?

    • 57 rachelcreative September 18, 2009 at 5:23 pm

      My personal experience with amitriptyline proving effective for relief of pain and more than halving occurence of migraines – is that I’m able to do more with amitriptyline than without.

      But it doesn’t agree with everyone. And like the next comment says it can make you a bit groggy for the next 2-3 weeks while you adjust to the medication.

      I hope you find relief from the pain. Chiari Malformation is no joke! All the best.

  33. 58 Katty September 16, 2009 at 4:52 pm

    I was having daily migraines/headaches with visual disturbance and nausea. This went on for many years, I thought it was “normal” to be chugging the aspirin like I was. My husband encouraged me to go to the dr. My GP put me on 10mg of Amitriptyline. The first 2 weeks I was very groggy, sleeping a lot, it seemed intolerable, but I stuck with it and I’m glad I did. After that I got used to it and had no side effects. After awhile, it wouldn’t even make me tired at night. The headaches started to come back and I’ve since upped to 40mg a night, which seems to be working, zero headaches.

    I take it at 5pm, so that I’m not groggy in the morning. Keep in mind that every time you up the dose, it’ll take you a couple weeks to get used to the side effects. If I’m going out at night with friends, I’ll only take 20mg at 5pm, and then take the remaining 20mg when I get home. The slower you raise the dose, the less likely you are to experience side effects. Keep in mind there are some people who take 300mg of amitriptyline, and they’re not passed out all day.

    Over all, I’m very pleased with the drug. Yeah, sometimes I’m groggy, but it’s better than being debilitated all day with headaches and migraines. I’ve not noticed an appetite increase or weight gain, actually I’ve lost weight because now I’m not too sick to exercise. Occasionally I get dry mouth in the evening, but not too bad.

  34. 61 Loretta Gelinas September 30, 2009 at 5:24 pm

    Very interesting to read everyone’s comments. Don’tknow if you have heard of vulvodynia (I know, a funny name) but I have suffered with this for 3 years. It is irritation in the vulva, clitoris etc. The pain is different throughout the day. In the morning when I get up I feel swollen and then since I basically have to “sit on it” – it alternately feels chapped, raw, painful etc. but I am thankful it is not also itchy which apparently is also an effect. I’m 68 years old but my doctor says my pain is indicative of a 20-30 year old – perhaps because I’m still taking hormone replacement medications.

    I’ve tried everything suggested to get rid of this but to no avail. The specialist just put me on 25 mg. of amitriptline and I take it before bedtime. I’ve been taking it for 10 days but haven’t noticed any difference in the discomfort. My mouth is a little dry and I do start yawning about 8 o’clock at night. I’m hoping this medication will evenutally kick in as I think my next alternative is botox, although, I don’t know if this is something the specialist will agree with. When I go back December 17th, I’ll have to discuss this if there is no improvement.

    As mentioned, I’ve had this for over three years and didn’t even know it had a name until about 6 months ago. Very frustrating. I no longer wear underwear, cannot tolerate slacks or jeans. I went to the beach twice and immediately had to get my bathing suit off as I couldn’t stand it. Hope there’s an answer somewhere


    • 62 rachelcreative October 9, 2009 at 9:39 am

      I hope you find an answer too! Maybe your doc will increase the dosage to see if that has an effect. Different people seem to have different tolerances to it.

    • 63 Irma Joyal August 10, 2012 at 11:24 pm

      hi I have had vulovdynia since I was 51…I am now 74…the pain is a horrid burning sensation and it doesn’t matter if you are doing anything of just sitting quietly. I have been on amitriptylin on and off for the past 23 years. I switched from my neighborhood pharmacy to a mail in pharmacy and the pills the mail order pharmacy sent a different colored pill (red) and after I took 4 pills at night for 2 days the burning pain came back. I had to call my doctor ( try and reach a doctor today….almost impossible) and had him send a script to the neighborhood pharmacy for the original pill (white). The white pills says Amitriptylin HCL, the red one just says Amitriptylin and now I am wondering if there is a different make up of the red one that isn’t in the white one. Tonight I will be back taking the white one…4, 10mg tablets and hope the burning will subside. Anyone that has vulvodynia will take or do ANYTHING to get rid of such horrendous pain. Just hope you NEVER get it…problem is, no one knows what causes it.

    • 64 Varsha November 12, 2012 at 10:39 pm

      Hi, I have seen your post, and I know exactly what you’ve been through. I am in the same boat. Have you found a cure yet?

  35. 65 Gerry October 8, 2009 at 11:29 am

    The best cure for “dry mouth” is sugar free gum. Also helps prevent tooth decay, must be sugar free though.

  36. 66 Prunchie October 8, 2009 at 7:45 pm

    I was prescribed Ami last week for a problem i’ve had for 15 – 20 years.My digestive system goes into spasm having passed a stool.I get hot flushes,sweats,sometimes with palpitations.I then get a burning sensation and my energy levels die.I’ve been visiting my doctor for a long time,always complaining with this.I took the prescribed dose of 20mgs at night.When I woke the next day I was shocked to realise I had slept for hours,I had a heavy head and felt a little disorentiated,however the discomfort had gone.I took the same the next night and woke again very late.I went to town and felt dopey all day and almost got a panic when driving home in traffic.I’m wondering if this is normal initially and do these side effects wear off.Also my doc said they were non addictive.I’m not so sure I believe him.I don’t trust doctors anymore as you can imagine.

    • 67 rachelcreative October 9, 2009 at 9:38 am

      It does seem to vary person to person and a lot will depend on the dosage.

      My GP advised to start taking it gradually. So I started on 10mg and went up to 20mg after I think 2 weeks.

      When I started taking it, and then after increasing the dose, I felt dopey and a bit disconnected for maybe a week. Then this started to lessen.

      So it might be worth sticking with it for a week or so before you see if those effects are temporary. It’s going to be difficult with having to drive. If you feel too dopey to drive you might need to find an alternative arrangement for a week? If you can.

      I once took amitriptyline for despression a long time ago at about 75mg 3 times a day and felt like a total space cadet for the first week. I could hardly function – it was like being very drunk all day long for the first few days.

      I now take my dose 10-12 hours before I want to wake up, rather than last thing at night. I used to feel a bit groggy for a few hours in the morning. Now I take it about 8pm and wake feeling brighter.

      Hope this helps a bit.

  37. 69 Mandy October 13, 2009 at 8:25 am

    Wow, these comments are very helpful. Just diagnosed Amy for my constant neck pain as it is now making me depressed. I was reluctant to take it but after reading some of the posts I’m going to start tonight.
    I’ll keep you posed. Thanks.

  38. 71 Karen October 14, 2009 at 8:02 am

    I take 50mg for chronic pain and depression (a result of the chronic pain). It works great for the depression, I feel like myself again. It has helped with the pain but not taken it fully away. For about 4 weeks when i first started I was so drowsy I felt like I was drunk. I had alot of difficulty following conversations and getting out of bed. But then it really kicked in and I now get up at 6 in the morning before my alarm! It’s really given me my life back. I still get dry mouth especially at night and I feel warmer than I used to. I no longer wear long sleeved tops
    under my work gear. All things I am happy to trade for the depression and pain. I take my tablet at about 7pm and find I have around 2 hours before I get really sleepy. If I take it later it puts the whole next day out. I am going to try the split dose mentioned above,next time I go out with friends.
    I also suck on sugar free lollies in the evening and morning and it helps with the thirst. I am also convinced the hunger is due to the thirst (for me) and I drink a glass of water before eating anything. It has helped. I was putting on weight b4 this plan and it is now starting to come off again (though slowly). Now I feel more like exercising and am able to so hoping that will also help

  39. 73 Cheryl October 29, 2009 at 1:02 pm

    I am about to start on 10mg Ami and am scared stiff because of my reactions to meds. I suffer from Fibromyalgia and cannot continue with the pain killers and anti inflams. Wondered if I should cut the 10mg in half and start really small.. what you think…..enjoyed reading all the info and candid responses

    • 74 rachelcreative October 30, 2009 at 10:43 am

      I have heard of people doing that in order to adjust to them. But mine are so small I’m not sure I would be able to cut them in half. Maybe crush them and split the powder would work.

      Good luck with it. Hope it helps and you get on with it ok.

    • 75 Vera November 6, 2009 at 12:25 pm

      Cheryl, I’m just like you, My doctor thinks I have Fibromyalgia and percribe 10mg, hate pills, really take good care of myself.
      How are you doing? Not sure if I’ll get the percription filled?

  40. 76 BARRY November 1, 2009 at 12:42 pm

    In 2007 I had to have a total hip replacement but unfortunately the implant became infected and the leg became very painfull.
    I could only sleep between one or two hours a night due to leg pain and constant fidgeting.
    I started to get severe headaches using C0-codamol and the feeling of wanting to be sick using tramadol.
    I was prescribed Amitriptyline 20mg and taken off the other two medications. At first I felt very dopey and off the planet but as my body got more used to them these effects subsided.
    I take two tablets at night and soon fall asleep without pain of fidgeting and get a full nights sleep.I wake with a very dry mouth and black tounge and the taste in my mouth is foul but soon relieved after brushing my teeth.
    Drinking water tastes horrible so I add orange squash or drink flavoured bottled water.I had to have another hip implanted in October and I am still taking Ami.
    At this moment in time I feel much better and able to carry on throughout the day without too much trouble.
    I hope they carry on giving me relief until I am taken off them.

  41. 77 jo in essex November 9, 2009 at 5:48 pm

    hi thank you for ur post
    i have just been diganosed with chronic pain syndrom AND join hypermobilty and was given today amitriptyline as a painkiller and to be honest i thought my doc was trying to trick me in to taking anti depressons as i have told they before i wont take them as i am not deressed

    but reading ur post has given me the corage to acterly try this medication i have been given th 10mg for now but have been told next time it will be 20mg then on to 30mg i wil come back and let you know if it has been a help to me

    i am also a mirgrain sufferer so if this helps with that it will be a mega bonous as mirgrains have plag me since puberty

  42. 78 BARRY November 9, 2009 at 9:39 pm

    Hello Jo,I have found out from my Doctor that the black tongue I suffer from is caused by some very strong anti-biotics that I am taking.
    Hope all goes well for you,good luck.

  43. 79 Summer January 13, 2010 at 3:30 pm

    I started taking amitriptyline 2 months ago after a year of chronic fatigue/pain and anxiety. I am currently taking 12.5 mg in the evenings, however, today was the first day where I could not wait until the evening, my pain and anxiety got to be too much. I have had very little side effects on this drug and have foind it to be very helpful.

  44. 80 ldenise February 14, 2010 at 8:39 am

    I started taking 10 mg and I had some side effects so I stopped taking it cold turkey. BIG MISTAKE! I sarted going through withdrawal which was horrible. My doctor put me back on it at 25 mg and the first night I took 2 and went to sleep. The second night I took two and I’m still awake at 2:00 in the morning writing this post. I am restless but not sleepy. I was thinking about upping my dose to 75mg (3 pills) but I am scared. Well good luck to everyone.

  45. 81 janette kreft March 24, 2010 at 3:51 pm

    just got my ami tablets have not taken them yet. a bit worried about the side effects etc. i have got them for chronic knee pain. i am on 10mg a day to be taken at night. as a women one of the side effects which worries me most is putting on weight!! has anyone out there put on weight while taking ami.
    also do you have to take them every single night or can you just treat them like a painkiller taking them as and when you need to. I always seem to forget to ask the doctor important stuff like this!

  46. 82 ruth May 12, 2010 at 1:16 pm

    Hi…..I just started amitriptyline for pain in urethra. Can anyone tell me if this has worked for those with the same problem and also does it become effective right away or doe you have to build up?


  47. 83 Angela May 12, 2010 at 6:58 pm

    Hi my name is Angela and today I’ve been to see a doctor at a specialist pain clinic and he is writing to my GP to advice starting on Amitryptiline.I have had chronic pain for 3 years now following two discs rupturing on my left side and this led to my sciatic nerve being crushed and permanent nerve damage being the end result.
    I had a lumbar microdesctomy in July 09 and this relieved the back pain considerably, however because of the damage to the nerve I have been left with permanent pins and needles and shooting pains in the bottom of my left foot,leaving walking very uncomfortable and after a couple of hours at work I have to go home and put my feet up for a good couple of hours and sometimes the rest of the day.
    I have been on various meds for the pain over the last 3 years(oramorph,zomorph,diazepam,gabapentin and cocodamol) and at the height of the pain on considerable doses. I now have no oramorph, have over halved the zomorph 30 mg in morning and 20mg in the evening as opposed to 60mg and 60mg,have gone from 3 lots of 5mg diazepam daily to 2mg maybe 3/4 times a month to relieve sever muscle spasms but remain on full amount of gabapentin 3600mg per day.
    Only the gabapentin helps with the nerve damage and the doctor says that the Amitryptiline will dull the nerve reactions and therefore stop/reduce the pain however I am extremely anxious about feeling sleepy and putting on weight? Any advice or support will be welcome as I will be starting these when my doctor gets the letter(maybe a week or so).Thanks all and hope I’ve not bored you.

  48. 84 Leah July 28, 2010 at 8:51 pm

    Hi, I have been having chronic neck pain and subsequent migraines resulting from neck pain/trigger for past 5-6 years. Finally convinced my gp to do a ct scan after trying so many painkillers with zero results. My ct scan showed I damage at c6 that causes the nerve to be pressed down which triggers my migraines. They said it has a slight bulg and degeneration at c6….oh fun.

    I have tried several options and went back 2 days ago to try and get more help from my doctor and she put me in Ralivia…..with percocet for some pain. Well, 24 hrs after I was in the ER with one of the worst migraines, to the point I couldn’t keep even tiny sip of water down and certainly no meds or gravol…..they pumped me full of stuff and within an hour I was so much better. The doctor in the er said my gp was wrong to give me ralivia and percocet as they trigger rebound migraines…..great. He gave me a prescription for Amitriptyline 10 mg to try for a month and possibly get higher if my gp (not alot of faith in her at this point)feels I should.

    Reading this blog has really helped me feel better about it and taking it. I’ll try 10 mg and see how that goes. I am only 43 and have 4 kids at home who are very busy busy busy, as I am, so I really don’t have time for this horrid pain which is very frequent….

    Good to hear others experiences with this medicine. Love to hear more.

    • 85 rachelcreative August 1, 2010 at 3:06 pm

      Hi Leah. Thanks so much for taking the time to comment and telling your story. It’s great to hear sharing experiences is useful to others.

      Low dose amitriptyline has certainly helped free me from almost constant migraines. I still get them from time to time but the amitriptyline does a lot to keep the lions share mainly at bay. I hope you get some relief. It’s no fun battling with migraines.

      • 86 Doreena August 12, 2010 at 11:35 pm

        Hello I find this site very comforting. I also was prescribed 10mgs ami for insomnia and pain. can anyone tell me in at this low dose, is feeking groggy in the morning a major concern. I have not taken the med yet.
        I was thinking of trying just 5 mgs to start, has anyone tried this? thanks for any help

        • 87 rachelcreative August 13, 2010 at 10:33 am

          I’m no expert. A lot would depend on how sensitive you are to the medication as 10mg is really a very low dose.

          If you do feel groggy in the mornings you could try taking it a bit earlier in the evening – about 10-12 hours before you want to be awake. That certainly helped me

          Although I did personally have a couple of weeks of grogginess as a side-effect when I started 20mg and again when I went to 30mg this wore off by week 3. I do have ME/CFS though and this tends to make me more sensitive to medications.

          • 88 Doreena August 20, 2010 at 12:43 am

            thank you very much for taking the time to reply to me. I think it is time to give it a try for insomnia I am not working fo a couple of weeks so I can see how I react to the grogginess feeling I hear about. thanks again hope u are feeling well.

        • 89 Melissa October 27, 2010 at 8:14 pm

          I wasn’t too groggy with 10mgs but did notice the difference between 10-20mgs. I’m taking it earlier in the night, so I wake up for work in the morning! You must have been on it for a couple of months now, how do you find it? I’m only at 20mg but I’m supposed to jump up to 30mg next week for insomnia and pain control.

        • 90 nola September 22, 2011 at 12:06 pm

          I have also been given 10mg of Trepiline at night and was nervous to take it. I cut them in half and took only 5mg, but did not find much pain relief (severe sciatica and knee pain). I have decided to try the 10mg at night and after reading comments on this site I feel much better about doing this.

  49. 91 iceskatemum August 12, 2010 at 3:29 pm

    I found your blog re ami very interesting. I fell nearly 8 months ago and have now got bad chronic pain. I was at a pain mgt clinic and they recommended a Butrans patch and lyrica. Unfortunatly I found the lyrical very debiliating and after consultation with the GP he has recommended trying amitryptylin. at first I was very hesitant having been prescrbed it 20 years ago for post natal depression but I am glad to say that it seems to be working although I have needed to go up to 20mg about two weeks ago. My one problem is feeling very tired and sleepy in the mornings. This is followed by around three/four hours of feeling OK ( provided I don’t over do things).
    After reading the blog I will try and take the meds that bit earlier and see if this helps. My aim is to get back to work in the near future and the morning sleepyness will def not help that.

    thanks again for th blog

  50. 92 Debsgro August 17, 2010 at 8:32 pm

    this blog has really helped me gather as much info on taking ami 10mg, after having an anal fissure i have now been left with alot of pain after bowel movements even though after examinations the doctors can find no reason for my continuing pain so have given me the option to take this, my main concern is that of feeling tired and dopey because in my teens i suffered from a few epileptic fits and that feeling of not being with it worries me, i am now 41 and a busy farmers wife but the pain has domenated in the last few months…

  51. 93 Browniegirl August 23, 2010 at 5:37 pm

    Hi all, well I’ve been I thought I’d write back with my update. I was initially given prescription for Ami in the hosptial while in for a horrid migraine, the doctor started me at 10mg but told me to up it in a week or so if I got another migraine. A week later I had another migraine, so I upped it to 20 mg. I saw my reg. doctor and she put me on 25 mg. I’ve been on 25 mg for a week now……..I, unfortunately, had a migraine on 25mg yesterday…..(neck/disc problem that triggers migraines) and after many hours during the day it stopped. Weirdly enough, the last couple migraines I’ve had have started at top of my head as opposed to the side of my neck where the damage is….although once it starts, it goes down to my neck, very very strange! I want to keep taking Ami and I pray that my migraines get less and less……..I have been referred to a pain doctor but won’t get in until November. I have found no pain meds that help me once my migraines start, any suggestions? I’ve tried advil, codeine, tylenol, percocet, and Im sure many more, with zero help, they just make me sick to my stomach and feel worse, can’t win……….has anyone else found an effective pain med once their migraines start?? thanks all, I really like this blog as it can help us all!

  52. 94 wstcoastgirl August 26, 2010 at 9:28 pm

    Hello all, I want to know if anyone could help me with a question I have reagrding meds like ami. I was prescribed 10 mgs.for some insomnia and fibro syptoms. just took it for the first time last night. I didnt fall asleep for 2.5 hours after I took it. It is strong left me feeling out of it for hours. does this feeling go away when taking these types of meds? I am a working girl and I am off for a short while but do have to go back to work, does anybody here work also???? just want to know if you have anything to share with me that could help. thank you and wishing everyone a great day

    thank you so much

    • 95 Melissa October 27, 2010 at 8:25 pm

      I work also and am paranoid about taking it and not waking up on time! My doc said to take it around 8pm, but I’ve done 7pm. Last night I went from 10mg to 20 mg and really noticed a weak, heavy feeling when I woke up accidentally at 4am. I’m going to try 20mg again tonight but will maybe even take it at 6pm. How is it going for you? I need to be alert for work in the morning and need to be able to drive there too! I’m supposed to go up to 30mg next week. It’s to help me sleep and wake up feeling rested and not in pain (feet, back, all over achiness).

  53. 96 Joe Delaney September 4, 2010 at 10:03 pm

    Its great to read so many positive comments on amnitripiline. I have suffered from burning and tingling sensations in my left buttock and leg. I was diagnosed with Meralgia Parasthesia (trapped nerve) in and around my groin and had surgery in June of this year. Since my surgery, I have had severe referred pain and all of the previous sympthons have returned in a more severe way. My surgeon has just perscribed 25 mg Amnitripline to be taken at night. Just started this week, so now on the fourth night now. Now immediate relief as yet. Presume it will take time to kick in ?. Would like to hear any comments

  54. 97 oohay282820 September 5, 2010 at 7:27 pm

    Two weeks ago I started taking 25mg of Amitriptyline each night after being diagnosed with fibromyalgia and joint hypermobility. I was really groggy at first because the doctor told me to take it 2 hours before going to bed. I then read about taking it 10-12 hours before you want to get up, so I do that now and the mornings are better. I’m always a bit foggy in the morning anyway due to fibro anyway.

    My sleep is better and I also don’t have to get up to go to the loo during the night any more. Not sure why that’s stopped, but I’m grateful because before I was getting up two or three times a night.

    I was wondering, how long will it take for it to help with the pain? If I’m in pain when I go to bed then the Ami doesn’t seem to help me sleep or lessen the pain. Also, I’m still waking up with pain in my jaw and I’m still quite stiff.

  55. 98 Debsgro September 9, 2010 at 8:16 pm

    well i finally tried the ami 10mg for 2 nights, even on that low dose my head felt a bit strange and my hearing seemed to be amplified! also had a very unpleasant taste in my mouth…really dont like it so far and am wondering if these side effects will go away? not sure i would feel that safe driving while on these.
    any feedback would be welcome

  56. 99 iceskatemum September 15, 2010 at 10:49 pm

    HI there I thought I would update those that may be interested in how things are gong with taking th ami. I have now been on the 20mg dose for the last few weeks but have had an increase in the amount of headaches and stiff necks I have been getting. these are almost as dibilitating as the original back pain !
    I may have a chat with teh GP and see if I can try and reduce down again . I would rather have some back pain than the headaches etc.

    Again reading this blog has given me insight into the pros and cons of taking ami. I was beginning to think I was getting the headaches from taking a few paracetamol along with my patch!

    Good luck to everyone and thanks for the feedback, While I appreciate all that the Dr’s do reading how the drug effects others is also very useful.

    • 100 rachelcreative September 17, 2010 at 10:39 am

      Just to say that when I upped my dose to 30mg I got increase in my pain symptoms but these went after a few weeks. My GP hadn’t heard of anyone reporting that before so maybe I am odd. Just thought I’d mention it though as sticking with it for a few weeks has meant I was able to up the dose.

      Hope the 10mg takes the edge off for you.

      • 101 louise September 3, 2011 at 3:25 pm

        I am so relieved to hear this,as i thought it was just me.I have occipital and trigeminal nerve pain.Every drug i have tried lyrica,gabapentin,dosulepin,amitriptyline always give me more pain when i increase the dose,i cant take the pain and end up quiting the drug.I am in constant pain24/7 this is interesting to know that it wore off for you,because my gp said the same that shouldnt you worry somethings not right and come off the drug.I hope you have got pain relief x

  57. 102 Jen September 28, 2010 at 8:28 am

    Hi everyone. I’m so pleased to find this site! Where do I begin??! I’ve had chronic pain for around 6 and a half years in my lower back and around 5 and a half years in my wrists. More recently, about 18 months ago I began to get pain in my other joints such as elbows, left shoulder, knees (although I used to have knee and wrist probs in my teens – I’m now 27). I’ve finally been diagnosed with hypermobility syndrome. I looked this up it’s quite common for gymnasts to be hypermobile but don’t usually get the pain so the syndrome part is when u get pain from having flexible joints I think. I noticed when I was younger my joints seemed more flexible than my friends, such as fingers bending back to 90 degrees instead of 45, being able to put my hands on the floor in front of me without bending knees etc. My back pain began around 8 weeks into pregnancy and the docs couldn’t understand why when I was obviously not carrying any extra weight at that point. Well it’s now come to light after many years suffering, from a physio who recognised it instantly! I’m so relieved to know the cause of my pain but alas I am still in agony 24 hrs a day. I began 6 months ago on 15 mg codeine with paracetamol and ibuprofen which was increased to 30 mg 2 months later. Then Tramadol with para and ibu, then tramadol with diclofenac, now I’m starting amitriptyline. I took my first tablet 10 mg last night, at 8pm because I couldn’t bear waiting any longer for pain relief having been told to stop tram and dic. ITS NOT WORKING!!! I’m in agony, the worst in a long time. And I feel sick. I know it will take a while to build up and work but what do I do about my pain in the meantime? I just don’t know where to put myself. It’s 9.30 am how do I cope until bedtime? The only plus so far is I dont remember waking up at all last night, when it’s usually every 90 mins to 2 hrs. I feel groggy, which I expected but I’d hoped it would kick in straight away like tramadol did.

    If anyone can give me any advice I’d be so grateful. I asked for morphine but my doc said I’m too young 😦

    • 103 Jen September 28, 2010 at 8:36 am

      By the way I said it’s common for gymnasts but I’m not a gymnast! I’m a teaching assistant facing losing my job due to being signed off so much and the possibility that I may have to give up my career working with children that I’ve built because the pain is unbearable, possibly forcing me into becoming a receptionist or similar, sitting at a desk for the rest of my days. Ooh, that was a negative rant!!

      • 104 Jen September 28, 2010 at 10:35 am

        Just spoken to my doc as the pain is unbearable now who said I can continue with diclofenac and tramadol as required so hopefully pain will die down a little. I guess they were helping more than I realised

    • 105 ian January 8, 2012 at 4:43 pm

      i suffer from sicatica and lower back pain for the last five years.Im 32 years old and had surgery in march to relieve the siatica which took six to seven months for the pain to ease.Then my lower back started to get really sore in the mornings and i could barely walk for a least 2/3 hours.
      My doctor can not give me codiene as i have an addictive personality so im on tabs for arrtiris and 30mg of ami and only started with them 2 weeks before christmas.
      My job is floor laying so i sufferd a bit from deppresion because i cant do it anymore and i have two kids 9/3.
      Since i started with ami and the other tabs for arrtiris all pain has stoped and sleep has improved so much.
      maybe this might help hope you get well soon

  58. 106 Leah October 1, 2010 at 12:26 am

    Hi, I’ve now been on this for a couple of months. I started at 10mgs, didn’t work……dr. bumped me up to 25 mgs…….didn’t work and then bumped me up to 50 mgs after just over a month and I have to say… is working!!!! I take it about 1.25 hours before I head to bed and I find I sleep pretty darn good and although I don’t want to get up in the morning, I am just fine once I get up and not groggy at all! Maybe more so in the beginning, but not any longer. I have had a couple days where I thought a migraine was coming on as my neck started to act up but after taking a few liquid advil, it actually went away!!! I was practically at my wits end in the summer getting severe neck (bulging disc and nerve damage) pain and migraines at least once a week or if not more…..and now it has been well over a month since I have even had a bad bad headache!! I am cautiously optimistic that this is going to continue to help!!!


  59. 107 joedel14 October 3, 2010 at 9:58 pm

    Have been taking 25mg of amni for 4 weeks now. Have seen improvements in coping with nerve pain (after MP surgery). I forgot to take the tablet for one night and I was in severe pain for two days. Could missing out on the dose for one night have this effect, or, might it have been something else that triggered the pain.

  60. 108 Melissa October 27, 2010 at 8:06 pm

    Wow! How wonderful to have stumbled upon this site! I am 33 and have had awful foot and back pain, especially in the morning. I also have problems sleeping, which doesn’t help. My doc prescribed orthotics, as well as Apo-Ami. I started with 10mg a day for 5 days, and now I’m up to 20mg a day for the next 5 days and then I’m to go up to 30mg. After my first night at 20mg, my body felt funny. I took it at about 7pm (I’m paranoid I won’t wake up for work in the morning) and agree with taking it earlier as opposed to later. But I woke up around 4am and my whole body felt weak and heavy. I felt like I didn’t even have the energy to lift my arms or legs. Really quite odd and surprising. I was able to get up by 7, however, and felt fine after a cup of coffee. 🙂 but I am afraid of this heavy, weak feeling. Has anyone else experienced this? I think I’ll try the 20mg again tonight, maybe taking it even around 6pm. But I’m a little nervous about taking 30mg next week. I’m not using it for depression but more for it’s sleep aid and pain control.

  61. 109 Andy K November 5, 2010 at 1:55 pm

    Great to find this Blog , I have read with interest

    About a month ago I started getting very bad head and neck aches, the head pains got so bad that I have had morphine injected into me , no pain killers seem to work 100% , my doctor has told me to try these amitriptyline at a 20mg nightly dose

    Well I took my first dose last night and had no side affects or so I thought, no dry mouth etc, but today 15 hours later I feel really rough ,heavy headed, very tired/sleepy/sick/very groggy, I’m now very unsure whether to take my next dose?

    Think I probably will

    I`ll report back tomorrow at around the same time just so others can see how things go, Never know some one out there might be having the same problems at some point in the future and find this useful as I have others post before me

    • 110 Holly November 28, 2010 at 7:01 pm

      I’ve recently been diagnosed with Plantar Fasciitis & Tarsal Tunnel Syndrome. I’ve had pain in my feet for 13 years – you can imagine it gradually got worse to the point where I couldn’t walk at all without considerable pain. A botched right knee operation 5 years ago doesn’t help matters. So far steroid injections (3 weeks on) have exacerbated the heel pain and I’ve been housebound ever since. I was devastated last week when I was told that there was ‘no cure’because I have hypermobility syndrome. I’m only 41 years old and also have just been diagnosed as menopausal as well so left it too late for children. Double whammy. I have been referred to Rheumatology & a Pain Clinic. In the meantime, my doctor prescribed Amitriptyline 25 mgs. I took my first dose on Friday night – slept for 9 1/2 hours and woke up with much less pain in my feet and felt really good (although did get very slight dry mouth symptoms). So, I too was pleased that I had no apparent side effects and less pain. My sleep last night on it was really strange – a feeling of being half awake, half asleep but with an inability to move. Today, I feel completely ‘strung-out’ and groggy – slightly manic (defo not normal!), dizzy, not quite all there, poor memory and very very dry mouth. Just wondered how you got on if you continued to take meds

  62. 111 springer December 9, 2010 at 5:46 pm

    It’s been very interesting reading all of the comments. I’m just about to start to take Ami. for lower back pain. What I would like to know is will I still be able to take a glass of wine with my evening meal. It says to avoid alcohol but it doesn’t say why or how it affects the drug. Has anyone had any experiance and weather it will adversly affect me or the way the drug works?

    • 112 Leah December 15, 2010 at 11:03 pm

      Hi all, I just wanted to throw in my 2 cents on the question regarding drinking wine with evening meal. I have been on ami for almost 4 months now, my doc gradually increased it to 50 mg which has mostly worked. I have had some neck pain in the past couple of weeks but my doctor prescribed an anti-inflammatory called Toridol that has helped me manage the pain once it starts, fingers crossed…I’ve never found anything that has stopped the neck pain and subsequent migraine once it starts….

      I always drink a glass of wine (almost always unless driving in the evening) with dinner and I’ve never experienced a difference. It hasn’t made me more tipsy or anything like that, so for me, it hasn’t made a difference. So, although I’m not an expert by any means……..I would say to cautiously try it and see if you notice a difference. I know I didn’t.

      Good luck and let us know!


    • 113 rachelcreative January 14, 2011 at 11:40 am

      Sorry a bit late responding to this!

      I have a low tolerance for alcohol due to my ME/CFS but I would say that when I have had a drink I haven’t noticed it affecting the way the drug works. It may make the alcohol effects worse ( this was certainly my experience with high doses of other anti-depressants) but on a very low dose it may not.

      I’m not going to say it’s ok if the leaflet says not to drink. But I have had a drink and not noticed it meaning the pain killing effect hasn’t worked the next day.

      Be interested to hear if you do try it with alcohol what your experience is.

      • 114 springer January 14, 2011 at 5:34 pm

        Hi Rachel,
        I’ve just picked up my second perscription for 10mg of Ami. It took about 3 weeks befor my back pain stopped waking me up at night and has been fine until about 4 days after I finished them so I’ve got some more. Beings it was over the Xmas period I’ve been having a drink most days and apart from a dry mouth I haven’t had any other side affects so fingers crossed that I have found this solution..

        • 115 rachelcreative January 15, 2011 at 12:39 pm

          That sounds great!

          I had mine prescribed to prevent migraines but I also have bad back pain due to crushed discs. I’d managed some of that pain with lifestyle adjustments (ie not doing lots of things that made it worse) but it took me quite a while after I started ami to realise that it was really helping with the back pain. Now I only get it when I do stupid things (like lifting things I shouldn’t or sitting in ways that are bad for it).

          So pleased it sounds like this is a good solution for you also. The relief from that kind of chronic pain can be immense. Best of luck with it.

  63. 116 BM December 9, 2010 at 6:13 pm

    Thank you! I just picked up my first prescription and was scared to start the treatment, despite being in chronic pain most days from neck pain, headaches and migraines.

    It’s nice to know I’m not alone.

  64. 117 Vicky Wilson December 14, 2010 at 2:51 pm

    I was diagnosed with fibromyalgia three months ago. For a whole year I hurt all over and felt so tired and depressed. I felt as if my life was over. I had muscle twitches, back pain.. etc. The Doctor was even considering Motor Neurone. Started on 10mg of Amitriptyline and within three or four days I was a different person. I’m now on 20mg at night. Main side effect is constipation but apart from that I am 80% better. The neurologist told me it was a very effective painkiller but some people cannot tolerate it. I am glad I can.

    • 118 chrissycatcream August 30, 2011 at 5:17 pm

      Oh, that seems to be my side effect constipation dry mouth heavy feeling in my head, but will see how it goes,will now try and take amitriptyline earlier to see if i,m lest groggy, sleep pattern does not seemed to of changed yet still waking up on and off all night long, been on ami now 7 days tried pregabalin this morning really bad effects thought I was goin g to pass out plus visual disturbance, Teddy bears in my bedroom were moving , and seeing flashing coloured patterns not for me thank you very much, fibromyalgia sufferer……

  65. 119 Jilly January 11, 2011 at 10:31 am

    I am thrilled to have come accross this site and thank you everyone for your comments. I have suffered back, neck, joint pain, migrains and irritable bowel for about 18 months and had put it down to my work but recently took it all up with my GP and today he prescribed amitripyline for Fibromyalgia. I came home feeling excited to have a diagnosis at last but also very anxious and not wanting to even try it. My GP took alot of time to explain the diagnosis and the treatment and has started me on 10mg to increase gradually to 30mg. Having read all your comments on here I am now keen to try them and will start tomorrow evening 12 hours before I want to wake up. I am also hoping to not need sleeping tablets anymore. Who knows they may even lessen my carpel tunnel symptoms. I will save this site to my favourites and update my progress from time to time so, watch this space 🙂

    Thank you all again so much.

  66. 121 miss m January 11, 2011 at 10:58 am

    hi i have been prescribed ami 10mg recently haven’t taken it yet – got freaked out when i read the leaflet inside which said it was an anti depressant. i thought my doc had prescribed the wrong meds. reading all your posts has calmed me down. i have nerve pain down my right leg which is on and off – i’ve been taking co-codamol which has helped but hate the constipation. my doc suggested ami – so now i’m still hesitant to take it. don’t want side effects etc..

    thanks everyone for potsin though it’s been very useful.

  67. 122 David Edwards January 12, 2011 at 9:23 am

    Hi I have come across this site and found some advice very useful. Was prescribed 10mg a night of this for chronic upper back pain along with co drydamol as and when required. Other painkillers like tramadol and diclofenac have just made me sick to the stomach so cant take these.

    Can anyone share of any experiences on such a low dosage? I hear of many side effects but these are mainly on higher doses. I can bare some side effects as long as it doesnt affect my day to day duties like my job.

    Also while asleep I usually awake 2 times a night to go to the loo. Someone mentioned feeling like treacle while walking to the toilet?

    Any help appreciated,

    • 123 rachelcreative January 14, 2011 at 11:34 am

      Hi David

      I’m on 30mg and I don’t have the treacle thing. Maybe when I first started but not now. I sometimes get up in the night for the loo although a sleepy head I’m fine and get back off easily.

      The only side effect I really notice is the dry mouth but having been on it for so long it’s just an ordinary thing for me and not a problem really.

      The benefit in pain management and for me personally cutting down on migraines is worth a dry mouth any day!

      I’d recommend taking it 10-12 hours before you want to wake up which for me helps avoid any slight grogginess in the mornings. I take mine around half seven in the evening and find I am brighter in the mornings than when I take it last thing before I go to sleep.

      I experienced side effects for the first 2-3 weeks of starting it and again when uppping the dose for 2-3 weeks afterwards. It was me who mentioned the walking through treacle. But like I say this passed after 2-3 weeks and now it’s fine.

  68. 124 DW January 18, 2011 at 11:43 pm

    I’m wondering if any of you are young? I have been reading about the side effects possible for young people. I have a daughter who is 18 and they are wanting to try Amitriptyline.
    I am severely worried as they mention suicidal thoughts and tenancies. My daughter is suffering from TBI (Traumatic Brain Injury). I’m scared to have her try it and very concerned for her if she doesn’t.

    Any insight would be greatly appreciated.


    • 125 Sandra February 19, 2011 at 5:15 am


      I realize it is a month later and you may have already gotten your answer, but I understand your concern and thought I would try.

      Being an anti-depressant as one of its main forms, Amitriptyline does have the mental/mood changes that are now a side-effect on most drugs. I have actually experienced this first hand at a young age – 18, 19 – as I was very sensitive to anti-depressants.

      If you decide (or decided) to go with the Ami, I would just monitor your daughter for any changes – even visible. This includes the following:
      A robotic personality or state of being
      Does not make proper facial expressions, or any at all really, mask-like
      Very sharp mood swings, almost in a stereotypical “menopausal” or “PMS” thought of way. Even if these mood swings are sweet or happy (crying at a Hallmark commercial, then loving the entire world, then wishing somebody could help the homeless…), they should be watched closely.
      I was told I was colder. Not really mean, just quiet and unresponsive. I also was very much into working on my projects and being solitary. I did not care for company, and things that always made me laugh could not even muster a smile. I was also told that my eyes looked duller, which was most likely due to my lack of enthusiasm for company.

      The thing is, this family of drugs can make you feel like a different person. But it is highly unlikely that a pill will be taken and then a day later – suicide. If you can discuss being very open about physical and mental feelings and changes with her, that would be great. Obviously the easiest way to know how she is doing, but some 18yr old girls are not quite so open. Also, if the TBI has caused a marked difference it may be hard to further monitor more changes.

      There is no way to be sure if your daughter will have this as a side effect. The best news is that it is completely preventable and the medication can be stopped and all should go back to normal.

      Always do what you feel comfortable doing as a parent. If a doctor is saying “but give it two weeks” and your gut is not trusting that, do not give it two weeks. Now, at 29, I have had to go off simple birth control within 5 days due to the strong hormones giving me negative thought process side effects. Do what feels right to you, and do not worry about being high-maintenance or a bother.

      Good luck with everything. I hope you are both doing well.

  69. 126 newlyresolved February 2, 2011 at 8:24 pm

    I’m just about to start low dose amitriptyline for pain relief. I am 24 and have hypermobility syndrome with chronic pain in multiple joints. I have tried codeine and diclofenac but the side effects to both were intolerable.

    I have been prescribed 10-20mg once daily at night and was advised to start at the lower end and work up if needed.

    I also have issues with fatigue and frequent headaches and having read this thread am optimistic that the amitriptyline will have beneficial “side effects” that help with these issues. Some weight gain would also be a plus for me as I don’t have the greatest appetite and struggle to keep weight on.

    I am not going to try it tonight as I am alone and would rather have people around me if it might make me groggy.

    It’s been really interesting and helpful reading about everyone’s experiences on this thread. I hope my experience will be a good one.

  70. 127 Liz Allen February 14, 2011 at 2:54 pm

    Hi Everyone,

    I started taking Amitriptyline (10mg) for suffering chronic tension headaches after suffering from the flu in December. As I was still suffering from the after affects of the flu and starting the medication and having those side affects as well, I came off it after nearly two weeks. I am now back on the medication as I want so much to get rid of these headaches. The medication really helps with my sleep, it is the sides and back of my head, my jaw and neck muscle that I find exhausting!

    I lost so much sleep whilst having the flu, and got very upset out of worry and frustration as the virus just seemed to go on and on, and now I have been left with these headaches. It has made me so miserable, I just want to have my spark back!

    It is great that there is somewhere where people who suffer from chronic pain can come together and share their experiences and find comfort in knowing that they are not alone.

    Take care and hope you are all doing well.


  71. 128 Sandra February 19, 2011 at 4:55 am

    I just wanted to thank you and all who commented for this information.
    I think any time there is chronic pain, it is so taxing trying to finally find something that works. And on top of that, wondering why the doctor suggests this or that? I have physical therapy set, but also on drugs and it gets all confusing to somebody new to the pain game!
    I am very glad to read that this does help with pain, as I start it tonight. After almost 8 months I am hopeful about something helping my pain. Knowing that it is more than an anti-depressant (I am already on one! not judging it!) reassures me that my doctor is not just shrugging and suggesting it is all in my head.
    Unfortunately, some in my family do think it is, so I am sure they are happy I finally have an anti-depressant “that works.” Ah, family. But hey, whatever gets them off my back and also stops my pain HAS to be a miracle drug!

  72. 129 chita cotton February 22, 2011 at 5:52 pm

    Hi, Have been on the above for approx 2 to 3 weeks now, on 10mg.
    Have exp shaking in the hands, has anyone had the same symptons.
    Would like to hear from you. Thanks

  73. 130 Lin March 2, 2011 at 8:46 pm

    I started Amitrityline 25mg last night as I have 2 partially prolapsed discs sciatic and foot pain. Having tried other painkillers (Tramadol made me nauseous and sick) my GP suggested these ..there is so much negative about them on the internet I was worried about starting them but having also had really bad nights sleep I thought they were worth a try.. the first thing I noticed was a dry mouth ..but soon settled off to sleep I then woke a couple of times once with heartburn and then for the loo.. didnt find it too difficult waking at 6.30 but felt heavy eyed during the day as though if I shut them I would drift off.. but I also felt more able to focus and function in spite of the sleepy feeling in the background.. everything seemed to look a bit brighter then it has been.. I had a little doze(an hour) after my evening meal and will try taking them a bit earlier tonight.. has anyone else noticed heartburn? I was told it is ok to take a Ranitidine tab which has helped. I am worried about weight gain so will have to try and control my eating.. So far so good.. Thanks for starting this thread

    • 131 rachelcreative March 9, 2011 at 10:56 am

      I’ve been doing some reading about tricyclics recently and I think when you first start it can effect your liver enzymes but that settles after a while. Maybe that’s associated with the heartburn.

  74. 132 Kirsty March 30, 2011 at 5:41 pm

    Thank you!!
    I am currently being referred to the ME/CFS clinic and I’m also suffering with dreadful lower back pain… I am taking anti depressants as I have just had a bad bout of depression and my dr has now prescribed amitriptiline for pain relief… If your blog is anything to go by , I feel hopeful 🙂

  75. 133 stinky April 15, 2011 at 10:01 pm

    I would just like to say that alot of the negative feeling about amitriptiline stems from the days when it was just an antidepressant, the doses that could be prescribed were in alot of cases very high add to that other meds and the result was often instant zombie.In exess it is not a pleasant drug to take or in the case of some mental hospitals be administered.It seems to me that as a releif from chronic pain it works very well, but I also beleive that some negativity may come from some people whose level of pain did not warrent such a prescription and therefore had a bad experiance with these pills.

  76. 134 EffEmm April 21, 2011 at 3:44 pm

    I have been on 20mg/day of amitriptiline for the last four years, prescribed for migraine vertigo (fast occurring dizzy spells with nausea, cold sweats and then lethargy for several hours). It has for the most part kept the episodes at bay with occasional flare ups. As far as the pain aspect of it, I really can’t say it works that way for me, I still get muscle and back pain at the same level as I did before taking the medicine.

  77. 135 sharon May 1, 2011 at 7:35 pm

    i have been taking ami for a month now as i have chronic lower back pain after an accident at work left me with 3 prolapsed discs 18 months ago, i have tried everything had bad reactions to lots of medication including tramadol, i have had accupuncture and many other therapies all without sufficient pain releif, i took 2 10mg amitriptyline the first 3 nights and i was like a zombie but i had very little pain so i was happy to carry on with the medication i did try taking just one but the pain comes back around mid afternoon so went back to 2 tablets, the side effects have settled down now and it has changed my life, i still have some pain but it is much improved and i feel i have finally found something that works, i have’nt had a dry mouth or throat or any other side effects and feel lots better, i am waiting to be refered to the pain management clinic but feel more hopefull than i have in over 18 months, will post again soon hope anybody who is in chronic pain reads some of our mail and will be encouraged to try amitriptyline

    • 136 ian January 8, 2012 at 5:13 pm

      Hi Sharon
      You say your being refered to a pain management clinic and yet your pain is almost gone.
      The reason i ask this is im on 30mg of ami and my pain is also improved ten fold but my doctor has refered me to a pain speicalist and im wondering what good will it do if i have the pain under control.
      I suffer with 2 prolapsed disc’s and have had surgery for my siatica.
      Hope you get well soon.

      • 137 Martha Perry January 16, 2012 at 12:57 pm

        I was a nurse, spent most of my career as a palliative (working with folks with chronic pain) and hospice (terminal status) nurse. I know most of the “tricks” of the pain trade, so to speak. My life changed so much for the better when I went to the MGH pain clinic (had gone to a local one a couple times which was disappointing). The staff at the pain clinic have helped me in more ways then I can say.

  78. 138 sadie May 3, 2011 at 8:42 pm

    started on ami 2 weeks ago for migraines not sure if working now take 20mg -waiting for my next period sa hormone related side affects not to bad nice to know so many others are taking it as i wasnt sure about it

  79. 139 sarah May 6, 2011 at 10:37 am

    Hi everyone ,
    I have been reading through the posts and it has been a great help .I have been prescribed this in a 10mg dose for abdominal pain that i have had for the last 4 months .I am really scared to take it as I have 2 small children and im scared I will feel to groggy to see to them in the night if needs be and not be able to cope in the morning .I am wondering if I should halve the dose or not ,any help appreciated

  80. 140 sarah May 7, 2011 at 7:21 am

    well I took the first dose last night 10mg .I didn’t notice any side effects .I did have good sleep,where some nights I wake stressing over things but last night apart from getting up to see to my toddler was fine .I didn’t feel too bad getting up either ,not sure if ill up to 20mg will see how I am after a few days ,this morning I did feel a bit groggy but after 30 mins feel great so will keep you all updated

  81. 141 sarah May 8, 2011 at 10:58 am

    2 nights in a row no side affects as yet ,good nightls sleep ,but no pain relief as yet

    • 142 Tammy May 20, 2011 at 3:47 pm

      Hi Sarah, I have been reading the posts with interest and I am glad to see a fellow abdominal pain sufferer. (If glad is the right term!)
      I have had abdominal pains for over 7 years now, and have had many investigative scans and surgeries, finding endometriosis, twisted intestines and also adhesions attaching organs to my abdominal wall.
      I have recently been prescribed amitriptyline 25mg at night and have been taking it for 2 weeks now. I haven’t had any decrease in my pain, but do find it difficult to get out of bed in the mornings.
      After reading these posts, I will try to take them earlier, but I work evenings and finish at 10.30pm so this may be difficult! I find waking in the night with either of my two young boys isn’t a problem, just the mornings.
      I hope that your meds keep improving for you.

  82. 144 Susan May 21, 2011 at 4:23 pm

    I have been on 10mg amitriptyline for 3 wks now for migrains due to homone changes ( being of a certain age). This is the second meds I have tried the first did nothing. I am finding the ami helps a great deal but I am taking about
    8 presciption migrain pain killers a wk instead of the usual 12. My gp did say i could take a higher dose and I think I will have to. I see gp this wk, because I am tring to take less pain killers and have a life. The constant migrains and threat of them is making it difficult to arrange doing anything. I am going away next weekend, I’m the only driver so it is a worry. I get the dry mouth and throat but not to bad it doesn’t make me sleepy, I wish it did as I don’t sleep very well. I’ve never had to take regular meds befor so I was worried about taking a anti- depressent but having a daughter with mental heath issues(thefor taking much stronger meds) and realising the small dose I take I realise a lot of us are ignorant about the use of small dose anti-depressents. Does anyone have any icthing of the skin, I don’t know if this is my homones or the meds.

    • 145 rachelcreative June 1, 2011 at 8:38 am

      When I got to 20mg that really helped my migraines. Most of the migraines I get now tend to be around my period and are less severe (I’m on 30mg now) though I can still trigger them by doing too much (part of my illness is feeling ill when I exert myself too much).

      It really is a tiny dose compared to the dose needed for a therapeutic anti-depressant effect.

      I haven’t had itching skin with amitriptyline personally. It does mention an allergic reaction is possible in this article but I think that’s pretty rare.

      It could be another tricyclic from the same family might suit you better if the itching is related to the amitriptyline. Docs tend to go for amitriptyline first as it’s cheap and widely used but there are sister drugs available.

  83. 146 Gavin Brydon May 27, 2011 at 8:46 pm

    Nice post :-), I went to my doctors just over a month ago as i’m currently wiating for an operation on my wrist to correct it (Basically when i was 12 i fell over and broke my wrist, but the doctors didn’t allign it properly) So it’s not alligned properly, i’ve been in severe pain when i use my wrist. I’ve been on Tramadol for just over a year and the effect on the pain killers started to wear off so i went and saw him.

    My doctor said it was an anti-depressant but only at a high dose a 10-20mg dose is fine to help with relaxing the nerves that are causing the pain.

    I must say though that this tablet is wonderful! I’m almost painfree! :-).

    One thing i hate though, a little while after taking the tablets i feel like the bottom half of my body doesn’t belong to me. So it’s hard to go to the toilet and walk. But by the morning them effects have worn of and i’m painfree so once i take the tablets i go straight to bed lol.

    Operations on 8th of May, so once i’ve recovered i can slowly start to wean off my tablets :-).

    Thanks for the article 🙂


    • 147 Gavin Brydon May 27, 2011 at 8:58 pm

      Just another note, I’m not taking my Tramadol as much anymore since being on these tablets :-).


      • 148 rachelcreative June 1, 2011 at 8:31 am

        That’s great Gavin. I had to take tramadol recently just for a few weeks and coming off it was awful. I did get that walking through treacle feeling when I started amitriptyline but it wore off for me after some weeks (maybe 4-6 weeks I forget).

  84. 149 Carrie May 29, 2011 at 6:55 pm

    Wow, can’t believe how many people there are out there suffering from different pains. I just took my first dose of 10mg. for the burning pain from Shingles! Enjoyed reading all the comments and am a little more relaxed at starting with this drug. Hope to only be on it for a couple of weeks.

  85. 150 fiona May 31, 2011 at 1:02 pm

    hi, sarah how are you and how are you getting on with the amptriptline? i was on them along time ago for depression etc and i think all i suffered from was a dry mouth and abit of weight gain, im suffering again with depression etc along with aches and pains and was thinking of giving them another go but im so scared

  86. 151 Derrick Shoemake May 31, 2011 at 6:46 pm

    When I was in the Army I shattered my wrist, did a lot of nerve damage, was in constant pain. My ortho was doing his best to help me with the pain……he prescribed me everything in the book….but no luck. One day he started going down the list of everything he had prescribed for me to take. As he was calling them out, he would ask me did it have any effect. He asked me how the elavil worked….I said the what? Then he realized that I had not tried this drug. He placed me on 10mg immeadiately, within a week the pain was subsiding……I was eating again….my depression was fading. Elavil was a godsend to me. It had no side effects, my family could not believe how fast I got back to being my old self again.
    Now I have a chronic pain in my ureatha….going to try Elavil again…….cross your fingers.

  87. 152 Fozlu Miah June 12, 2011 at 11:49 pm

    Hiya I been taking ‘Amitriptyline 10mg’ x 2 at night for last 1 month but I just had 4 x migraine attack in one month better then before but the worse was headaches I had 7 days in a row non stop headaches comes with a throbbing type the worse pain ever drives u mad but this tablets works on me but side effect does affect me a bit
    Please email at if any can help in a another way

  88. 153 Rebecca June 15, 2011 at 9:07 am

    Hi there. I have been having shooting pains in my head for 6 months now (right occipital area). Neurologist cant find anything on scans,physio beleives its cervicogenic headaches… There is no pattern to the headaches, except that they dont wake me up at night and that there are no triggers. Doc has prescribed amy to help with the pain, to try and break the cycle.. dont want to be on it for life. Took my first 5mg last night, no problem with grogginess.. Want to maybe try 10mg tonight, but dont want to feel weird in the morning… Thing is, if I take it earlier, will it make me feel sleepy and unsocial and want to go to bed? or will I be okay for the first 2 hours or so? so if I take it at 8pm, will I be okay until about 10 pm or so? and if I am on 10 mg, will I still be able to manage with 8 hours sleep?(get up at 6am?) Thank you

  89. 154 Susan June 15, 2011 at 8:15 pm


    I started on 10mg of amy and found it an helped , but some pain was still getting

    through so after a month I went onto 20mg. I have found this stops many of my migraine
    and when I do have an attach it is much easier to deal with. I take mine about 10pm at night but if I going to drive early in the morning i take it about 7.30pm. I have no trouble keeping awake at night but can be a bit sleepy in the morning.
    Have been taking 20mg for 2 weeks now and have only had 1 real migraine which was still a lot lighter than befor. I don’t care how long I have to take them because I was getting approx 3 migraines a week befor and taking many strong migraine pain killers, I was finding it hard to be able to go out or plan any trip. I feel more confident now that they are more under control.

  90. 155 Pennie June 29, 2011 at 9:21 pm

    Wow! This is a GREAT blog…exactly what I needed!

    I was diagnosed with Multiple Schlerosis a year ago, and have had a variety of symptoms that I won’t bore you with. But…two months ago I experienced a new one – a sunburn like burning in my legs and arms. Recently – within the past week or so – the pain in one of my legs has become shooting pains – like those you get from shingles. My nerves are nuts! I guess this isn’t uncommon with MS. (There are so many symptoms and surprises with this disease – ugh!)

    I was prescribed Gabapentin…and became sick…and I found out weight gain was a side effect. That freaked me out. My neurologist switched my med (because of the nausea I had on the Gabapentin) to Amitriptyline and I was secretly happy because I figured the new med wouldn’t cause weight gain…then I read this blog (weight gain wasn’t in the side effect pamphlet). I’m only on 25 mg. each night. I’m hoping it doesn’t affect me.

    My question is…do you think weight gain happens whether you abstain from food, or your appetite increases and you eat more? Because I can keep myself from eating…I think.

    I take my first pill tonight – and I can’t wait. It’s been two nights without any pain meds and I am ready to scream from the pain. Seriously.

    Thanks for your help.

  91. 156 NZBon June 30, 2011 at 7:53 am

    Thanks for all of the comments, great advice especially taking the medication earlier to avoid sleepiness in the morning.

    I started taking 10mg of ami, increased to 20mg, and now 30mg as I suffer from migraine headaches. I was getting at least one a week and would find I was wiped out and could not work. The only side effects Ive definitely noticed is being sleepy in the morning, its very easy for me to turn off my alarm whilst half asleep, not realising, and just keep sleeping! But this side effect is nothing compared with the constant fear of a migraine plus the amount of work I was missing because of them. I noticed a marked reduction in the amount of migraines at 20mg, but after having a random cluster of migraines my doc has recommended increasing the dose to 30mg. It has only been a few days so will see how it goes!

    Im wondering if anyone knows about the sun sensitivity aspect – what happens if you are exposed to too much sunlight? Are sunbeds a definite no-no?

  92. 157 Maryhelen July 11, 2011 at 7:20 pm

    Hi there sorry bother you all, i was wondering if anyone could help, ive just been put on to 50mg tramadol 4 times a day as well as the 20mg amitriptyline i take at night, i was in an accident when i had an emergency c/section 6 years & have had this nerve damage & hip/bottom of spine damage which cause chronic pain, codeine just dosent seem to work so thats why trying tramadol but im a little frightened with all the scare stories … please help.

    kindest regards

  93. 158 markymark July 13, 2011 at 1:07 pm

    Hi, great blog!. I’ve been suffering with chronic back pain caused by a prolapsed disc (L4/5) for around 2 years. My physio recommended amitriptyline, and have been taking 10mg for 5 nights. My pain has reduced somewhat, especially during the first half of the day. I’ve been sleeping heavy but not had any problems with drowsiness during the day. I do have a bit of a dry throat and tounge, but compared to back pain that’s much more preferable! I’m planning to up my dose to 20mg on the weekend and see what happens. Will post after this if people find it useful.

    • 159 markymark August 2, 2011 at 12:59 pm

      Update: I’ve now been taking 20mg every day for 2 and 1/2 weeks (previously I took 10mg for 1 week) for prolapsed disc pain. After an initial good few days, the pain has returned. It is perhaps not as consistently intense as it once was, but the drug is not as effective as I’d hoped as I still have a lot of discomfort particularly when walking. However, I will keep taking for a few more weeks at least to see if the pain eases. One plus has been a vast reduction in the number of tension headaches / migraines – down from about 2 or 3 a week to one every 10 to 14 days 🙂 Only side effects I’ve noticed has been a dry mouth, but this comes and goes and is a minor complaint. Getting up early can sometimes be difficult too, but I’m finding I sleep right through the night most of the time.

  94. 160 Jack Hughes July 18, 2011 at 7:07 am

    I had nerve pain for years, then one day was unable to walk due to some nerve issue. I started on Ami at 10mg a day at night, and after 2 doses, I had no pain and the walking problem had gone. After 3 months of daily 10mg I talked to the GP and we agreed 10mg every other night. That works for me. If I extend the gap, the pain comes back. The weight gain is quite bad, but the pain was worse. I always take minimum dosage of anything. But I can understand the issues about stopping.

  95. 161 Mechelle July 20, 2011 at 11:08 am

    I am so glad that i literally stumbled across this site. Thank you all for your comments, they have helped me immensley!
    I started taking 10mg Ami last night after being prescribed it by my Neurologist last week.
    2 yrs ago i fell and fractured L4 which crushed the sciatic nerve to my right leg. I was on Tramadol, and at one stage was up to 200mg at night, which left me like a zombie going to bed at 6.30 at night! I was forced to go “cold turkey” whilst in hospital for a non related Op to get off the Tramadol, and it amazed me that all the time i was crying with the pain in my leg, it was probably the Tramadol addiction, and my body wanting its fix. My symptoms have begun to get worse again, loss of bladder control, especially at night when asleep, and my right arm and fingers going paralysed, numb. So until i have or get a positive diagnosis for something which i can then work with, i will try the Ami. Thank you for the advice on taking it 10-12 hrs before you want to get up! Today was awful, up for work at 0630 and still feel really sluggish at 12 noon, lips tingly etc… Hope everyone is well and thanks again for the peace of mind and help :o) x Mechelle

  96. 162 Michelle July 20, 2011 at 10:09 pm

    I have been taking amitriptiyline 10mg for the last 10 days and have noticed a decrease in my pain BUT it has made my menieres disease worse :0( (this is an inner ear imbalance which makes you dizzy & sick).
    Does any one else suffer from Menieres , as I want to know if the dizzy/sickness will pass? Seems unfair if I get rid of one thing and it makes my Menieres Worse :0(.
    I don’t know what to do and I have noticed that my heart rate has increased, will this all sort its self out?
    Its so nice to have found this blog, so thank you for starting it

  97. 163 Sandra July 21, 2011 at 8:16 pm

    Hi, I have been worried about taking the Amitriptyline 10mg that I was prescribed today. I have a degenerative lower back condition and I also have spasm’s in my upper back. I take co-codamol 30/500, diazipam 2mgs and diclophenac 50mgs and these have not had a great deal of effect so I am hoping that the new pills will finally take the pain and stiffness away. Reading this blog has made me feel more confident about trying them.

    Thank you to everyone who has contributed to this blog, its been very helpful and informative.

    • 164 Sandra July 23, 2011 at 8:13 pm

      Update: I have been getting to sleep but I am only sleeping for 6-7hrs then I wake up at 6am. I followed the advice on here about taking the tablet early so I am not drowsy during the day, but I’m not really feeling any better yet. I am however very thirsty in the morning and I am trying not to drink to much coffee and instead I’m having a pint of water.

      I’ll update again once I have been on them for a few weeks.

      • 165 Sandra September 25, 2011 at 8:40 pm

        Hi again, The doctor has advised that I take 20mgs. I started upping the dose a few days ago but its not helping. I now have an appointment at the pain management clinic and my insurance company said they will pay for up to 3 injections. I’m really scared now. I cant do my job anymore and they are aboutto pay me off as there are no other jobs available that I could do. I cannot stand for long or sit for long and walking round the shops slowly is agony. Best wishes to everyone, I sincerely hope that everyone gets some relief from their pain soon x

  98. 166 Eva Mendez July 22, 2011 at 5:42 am

    I was just prescribed Ami for My Tention headaches and I’m very hesitant to take due to the side effects especially the weight gain!! I am also a social drinker does anyone have any input on alcohol intake and also, i would also like to know if sunbeds are a definate no??


  99. 167 Mechelle July 22, 2011 at 8:53 am

    Well, day 3 on the Ami…. Day one left me really sluggish all day, you know the feeling, like when you nod off on the sofa unexpectedly and wake up feeling like poo!!
    I followed the advice of everyone to take the Ami at least 10 – 12 hrs before i wanted to get up for work and Day 2, yesterday i felt a lot more alert.
    I have slept all through the night with no painful wake ups or pee breaks! so that is the first time in two years! Only thing that i have found yesterday and today is a very dry mouth, and the feeling when you keep thinking you have bad breath but there is nothing there…may have something to do with the fact that both yesterday and today i have had a hyper sensitive sense of smell…it is absolutely awful… bins smell, people smell of BO….even the choccie biscs at work today smelt of bacon…one of the guys said that he had been eating some bacon crisps before he put the biscs in the tin…eewwww, but proved a point that i am not going mad!!
    Will keep you updated on the weekend! :o) Have a good one Mechelle x

  100. 168 chris July 22, 2011 at 11:55 am

    I was prescribed Amitriptyline 10mg yesterday for chronic leg pain, i didnt feel any benefit, does it take a while to get into your system?

    • 169 rachelcreative July 23, 2011 at 8:45 am

      I’d say you need to give it 2-3 weeks at least. It’s not like taking a painkiller with an instant effect when you take a tablet. It does take a while for the cumulative effect to settle. Good luck.

  101. 170 Cindy July 22, 2011 at 11:05 pm

    I took 10 Ami last night for migraine control and have been messed up ever since. I could not sleep and have excessive adrenaline. It does not seem to want to wear off. I am not willing to play with this drug as it seems to make me feel pretty crazy.

    Can anyone tell me how long the affects from this tablet will continue? It has been around 19 hours

  102. 171 Marianne July 28, 2011 at 11:31 pm

    You sound exectly like me. Do you have a diagnosis of any sort. Good luck.

  103. 172 Danny August 1, 2011 at 10:20 pm

    What an excellent blog, I was given 10mg Ami weeks ago for sciatica/nerve damage but was worried about the anti depressant thing. However my dad found this blog for me and told me to read it and start taking the Ami. So been taking it for a week now, Sleeping a lot better, feeling groggy on a morning but gonna take it a bit earlier like you guys have recommended and I’m gonna speak to my gp about taking 20mg cos the pain is still quite bad through the day. Does anybody think i should give it another week before speaking to gp about upping my dose?

  104. 173 Mechelle August 4, 2011 at 12:38 pm

    Day 16 on the Ami, and the side effects seems to be dying down a bit. I still have to take the tablet at least 10 – 12 hrs before i want to wake up, which leaves me with a bit of a dilemma… on workdays i take it at 8pm, and by 9pm i am more than ready for bed and find it not too difficult to get up for work the next day at 0630am…but on the weekend what is the best thing to do…i don’t want to be in bed by 9pm on a fri, sat night…it just seems a bit old before my time if you know what i mean, but if i wait until 10pm i am usless before then on a morning when i get up to swim on both mornings at 8am…. sigh… at least all of the weird sensations have stopped bar the heightened sense of smell which i am slowly getting used to. Can i just ask? if i decided not to take them from tonight, would i get withdrawal symptoms? tempted to, only for my life to get back to a normal regular pattern. Hope you all are well x Shell 🙂

    • 174 pkish August 16, 2011 at 8:16 pm

      Just curious how it went with not taking it over the weekend. I am about to start taking Ami 10 mil. for the first three days and then up to 20mil for two weeks. I have a wedding to go to in a few weeks and so I am concerned what would happen if I didn’t take it on the night of the wedding as everyone will be up late!

  105. 175 Leah August 4, 2011 at 3:32 pm

    Hi all, I started Ami just shy of a year ago at 10 mg and then was bumped up to 25, then 50 in the wintertime due to nerve/disc problem in my neck. The 50 mgs finally helped with the frequency of the pain which helped with the frequency of migraines. I was getting 1-2 migraines a week and they were horrid!!! In the past 3 months I’ve noticed the pain starting up again a little more frequently and I have been taking anti-inflammatories alot more to keep the pain at bay but it was getting to be too much of them! So, my doctor has bumped me to 75 mgs and is hoping he can kickstart the Ami into working again. I was pretty groggy this morning but not too bad, I think I’m so used to the 50mgs that it doesn’t even affect me anymore, so that is a good thing. Was very concerned about taking such a high dose but my doctor said it really isn’t very high and we’ll re-assess in a month. Fingers crossed!!!


  106. 176 Michelle August 4, 2011 at 7:02 pm

    Hi Danny

    I suggest you give it another week before you up your dosage I have been on it for 3 weeks and the first 2 weeks I felt awfully dopey like you. I upped the dosage on Saturday 1st of Aug to 20mg and it really helps reduce the pain. I take my medicine at about 7pm and have found that it makes you less drowsy first thing in the morning its so nice not to be in so much pain and nice to sleep better at night.

    Good Luck


  107. 177 pkish August 16, 2011 at 8:22 pm

    Curious to know how quickly does it make you sleepy after taking the meds at night? I will be starting up on 10 mg for the first 3 days and then up to 25mg. My body type is petite, so I am wondering if it will hit me pretty fast (within 30 min -1hr).

    • 178 Ted August 25, 2011 at 5:45 am

      To answer Pkish

      When I first started on 10mg, the first night it hit me at about 1hr and literally knocked me out cold. I slept for 14 hrs straight. But then again, with my pain issue it was often hard for me to sleep well so I guess I was just catching up.

      The very next night, it again made me drowsy at just over the hour mark, but it wasn’t anything I couldn’t fight if I wanted to stay awake. I slept thru the night for the second night and for the following few days. At 4-5 days in, the pain that bled through woke me up at 4 hrs and every 2 hrs after.

      Once we found my optimal dosage (25mg), and by ‘we’ I mean my Doc and I, I can sleep through the night as long as I don’t give in to the urge to nap during the day (which is hard to resist) on my days off. If I don’t keep myself busy, I find I get drowsy – especially after meals.

      This isn’t a medication that you get ‘under control’ right away. It often takes a week or two to adjust and get your bearings. For example, when I first went to 25mg it took almost a week before I was comfortable driving. Since I live just over a block from work, at first I walked and then wouldn’t do anything but to-and-from until I got used to the loss of peripheral awareness.

      Also plan on having some issues with memory and focus. Wish I could say these went away, and if they do it’s more long-term than I’ve been on amitriptyline (which admittedly is just under 3 months now).

  108. 179 Liza August 17, 2011 at 4:57 pm

    I have great experiences with amitriptyline as a pain relief. I have cronical issues with my back and amitriptyline really helps.

  109. 180 Ted August 25, 2011 at 5:19 am

    Started on 10mg, which actually worsened my shoulder pain – as I was apparently mentally blocking a great deal of my pain on my own simply using OTC pain meds. Doc upped my dosage to 20 to see if it helped (which it did) but at my next refill took me to 25mg since at low dose it comes in either 10 or 25, and both cost the same so 20 was 2x as expensive. From self-experimentation, 30 was too much and left me groggy and zombie-like all day, while 20 left a tiny bit of residual pain. 25mg for me turned out to be the optimal dosage.

    There’s been a bit of weight gain (not bad – only 10 to 15 lbs total), and I have inconsistent bouts of dry mouth, but overall I’d have to say the side effects (including some odd dreams as well as the aforementioned) are well worth the pain relief in my shoulder. What used to be incredibly distracting at best and debilitating at it’s worst is now nothing more than a slight muscle ache (if I feel anything at all) at the 25 mg dosage. I also find I’m less angry at the world now that I’m no longer in constant pain, although the anti-depressant aspect may have played some part in that.

    All in all, I’d have to say that being put on amitriptyline has been a positive experience, despite my initial misgivings.

  110. 181 mark August 31, 2011 at 2:34 am

    Just read this blog having researched co.codomol,tramadol,diclofenic,diazepan and oxynorm.all of which im hospital with osteomylitus abscess on the spine caused by glad to find others who understand intense pain.sometimes afraid to try sleep.had 15hrs sleep in 11days because pain team do not include me in decision for amitriptyline i have not been told to take it earlier but this makes sense.Have been taking with diazipam and oxynorm at 11pm get 3-4 hrs sleep then wake to dull bearable pain.A godsend but dopey till midmorning.I dont care about addiction or side effects so long as the pain stops.Ive not even thought about how much if any mobility I will regain.My advice to anyone suffering intense soul destroying pain is never forget it is you who has it not the pain team.Understand what you are taking what it does and then find the combination that suits you until you have some respite.Then think about side effects and addiction.Do not let the pain team tinker unless you absolutely agree.They are not the ones screaming like an animal biting through their finger in the middle of the night.Im sorry for the poor punctuation but it is the middle of the night having had my meds changed again.You are alone with your pain so do what is best for you.Yes you will misjudge and get things wrong because you are so out of it but believe me you will know if something is right.When this happens hang on to it dont let some expert take it away.Forget being polite and reasonable.Just remember where that pain takes you in the middle of the night.Good luck to all of you,next time Im screaming in that hell I will listen for your voices and know Im not alone.

  111. 182 mark August 31, 2011 at 3:28 am

    Hi Rachel,Ive found all of these comment useful.Later when my one friendly nurse has time I will let everyone know my dosage.Probably the worst aspect of all is the venom aimed at the nurses simply because they are there.One always apologises but the sense that a bond of care has been broken pains the heart.

  112. 183 daniel September 16, 2011 at 9:02 am

    hi guys, i’ve been having increasing numbers of headaches and went to the doctor’s today and he’s put me on 10mg of amitriptyline for the next 4 weeks. i’m just a bit nervous about taking medication. i’ve never had to before and i’m concerned it’s the start of a slippery slope.

    i see dry mouth can be a problem but i’m ok with that if it stops my headaches. but i would like to know, for the people that have had to up their dose- how long did you give it before you tried upping it. 2-3weeks?

    i hope this works– i’ll keep you updated!

  113. 184 emma September 17, 2011 at 7:32 am

    Yesterday I took my first dose of amitriptyline 10mg
    I am very sceptic about taking that medicine at all.I had baby almost 8 monthes ago and a very traumatic
    labour and after 3 months of having baby Ive noticid Im not getting better
    I could walk wear jeans seat normal with out the pain
    Im still waiting for hosspital consultation because in my opinion there must be something wrong with the scar place
    all the other painkillers gels and local anestetics didnt work and my life become a nightmare
    there were days when I was so much in pain I could not even enjoy my baby and
    one of the ginecologist sugested ami
    I was a litlle bit dissapointed becauce I really think that there must be a reason for the physical pain
    but it does looks like Ill still ave to wait for the hospital apointment
    So I took the first dose and Im scaed how I ll cope with the small baby and the possible side effects
    your comments make me feel a litle bit less scared

  114. 185 Glenn September 18, 2011 at 8:18 am

    i was prescribed Amitriptyline 20mg at night back in May 2010, for the first few weeks of taking them i had strange almost real dreams, very wierd. This settled after a month or so, these tablets worked fairly well when mixed in with a cocktail of pain killers, but did not cure the problem, so i decided that i would rather aim towards finding the real problem and try to cure that than mask over it with these. i had to be come off of these slowly, you can not just stop..addiction?….so now it is 2011 and several different tablets combination and treatments later i can repoet no real change, the problems/pains with my shoulders, neck, headaches and severe back pain have not gone, but they have not increased, i am now due to see a Orthopaedics specialist and will let you know how things develope, this best thing with this blog is to see how many people are suffering the same as myself and worse, it is easy to think it is only you that is suffering and spiral into a path of self gloom….thank you for all the great reads and informative info. helpful Blog.surviving but not cured.

  115. 186 Barbara Taylor September 20, 2011 at 11:26 am

    Just started last night with 10 mg to help combat foot pain, had the best nights sleep for about 5 years and feel qite lively this morning. Don’t notice any lessening on foot pain yet, but Isuppose it takes time. Will be interested to see how everyone gets along with it.

  116. 187 thebiggreyelephant September 20, 2011 at 9:06 pm

    I have just been prescribed Amitriptyline 10mg to be taken at night, this is for serious lower back pain that I have had for a year and a half. The pain is so bad I can barely walk 30 metres before needing to sit or lean on something. I was a bit nervous taken this, as was my wife when I said it was an anti depressant. But reading this blog and the replies has helped a lot. I am really hoping this works as I don’t know long I can keep going before not being able to get out of the house. I’ll let you know how it goes. Thanks everyone.

  117. 188 denice neary September 26, 2011 at 12:51 pm

    thank you everyone for comments i have just started this med today and was worried about taking it. but im in so much pain in my neck, back ,“and shoulders i will try anything..i will keep a log and update on how it goes..hopefully i will get good results thanks again ppl for takin the time to share your experience with Amitriptyline much appreciated ….

  118. 189 Michelle Johnston October 3, 2011 at 4:03 pm

    Emma, did you have a c-section? I did 10 years ago and have nerve damage caused by the surgeon. I didn’t get this confirmed till 2009. I am now suing the hospital. Keep bugging your doctor and go see a lawyer.
    I didn’t start ami till this year and it has made a big difference to me. I totally understand how you feel. Love Michelle Johnston xxx

  119. 190 Susan October 3, 2011 at 4:47 pm

    I have taken 20mg Amitriptyline for my Migraine for about 4 months now, I started on 10 and 2weeks later increased it. I still get Migrains but I take Sumatriptan straight away and it does stop it becoming too bad, I can function and not be in bed in agony. I also take anti sickness at the start of my Migrains. I don’t really want to increase the Amitriptyline as it can make me quite sleepy sometimes the next morning and I srtill get vivid dreams even after 4months. I take it about 10 at night and it does help me sleep which I was having trouble doing. I find though that if I take co-codamol 30/500 for another problem I have it can corse me to have a Migrain the next morning. I was taking Sumatriptan nearly every day but that has inproved and now i take about 2/3 a week.

  120. 191 Mechelle October 4, 2011 at 9:49 am

    Well, i have been on 10mg Ami since 19 Jul this year, and have found the following: Take the tablet at around 7pm and i am sleepy by 9pm on a work night, means i can get up for work at 0630 quite refreshed. At the weekends, i can get away with 9 pm to be a bit groggy by 11pm, and better by about 9am the following morning… so i think the rule of thumb is the 12 hour window between taking the tablet and being okay for the next day…
    I have dry mouth, but have learned to drink more water during the day to help combat this, and have gained about 10lb in weight.. it must be a side affect, as i am still on the same diet, taking the same exercise as i was previously. I also now take Circ 8 for dizziness, caused by minears symptoms brought on as a side effect from the Ami, It started with dizzy spells if i looked up or down quickly… and also take metroclopamyde for nausea, also a new side effect….so all in all i am now on 4 tablets…. Naproxen, Ami, Circ 8 and Metroclopamyde, but it is woth it to get some relief from the constant gnaw of pain, especially through the night, when you feel you are the only person on the planet up and in pain.

  121. 192 Martha Perry October 4, 2011 at 12:12 pm

    Is there another name for “circ 8”?

  122. 193 Michelle Johnston October 4, 2011 at 8:04 pm

    The correct spelling is SERC :0)

  123. 194 Sandi October 7, 2011 at 11:41 am

    I have been struggling with a chronic pain/fatigue condition affecting my feet legs, hands, elbows and more recently shoulders. This started after a speedboat trip on holiday last September when I got badly jolted through my whole body. I am a physio so it is very distressing because whatever I do to help myself the pain doesn’t change – exercise definitely makes it worse and too much rest isn’t good either. My GP mentioned amytriptyline last time I saw her, as my kidney function has dropped which may be due to taking Ibuprofen (the only thing which touches the pain at all). I am seeing her again today as I have had a major flare up over the last 24 hours and have also found some swellings under my arms – hoping it is a reaction to some bites I had on holiday in Greece last week, but thought I had better get them checked out. I have really found this site useful, as I hate taking medication, but need to get on top of all this, so in balance the Ami looks as if it is worth a shot.

    • 195 Sandi October 9, 2011 at 4:01 pm

      Well, I am on Amitryptyline – my GP wouldn’t prescribe 10mg as she said that 25mg is very low, and that 10mg wouldn’t help my pain. I was quite unhappy about this and spoke to my pharmacist who said if the tablets were scored I could halve them and build up gradually. They aren’t, but I successfuly have cut them in half and had 2 doses.

      I took the first one at 9 pm and felt strange after about an hour, went to bed 2 hours later and found the effects very strong. I felt as if I was pinned down to the mattress, my body was so heavy, but my mind was still very active. Quite a strange state to be in, but I slept in 2 big chunks, more than I have for months. I was quite drowsy and felt very low in the morning, mainly because I had been worrying about it all, ached a lot across front of shoulders (because I had been in one position so long I think!) cried a lot in the day and decided I wouldn’t take any more. Thought about it more and decided that I needed to do something about this whole situation, and give it more of a chance, so had another half tablet last night at 8 pm – and almost immediately got weird symptoms in my chest, like cramp and down my arms. Tried to keep calm, and it eased off. Went to bed and it wasn’t as severe, still felt very heavy, but nothing like the night before. Slept on my side more, and woke more easily, and have had a much more productive day and felt much lighter and in control. Sooooo . . . . so far so good. Really going to try and keep at it, so that something changes in my sleep and pain patterns, hopefully my chronic pain pathways will get re-wired!!

  124. 196 Mechelle October 11, 2011 at 8:28 am

    Hi Martha, sorry i have been away, Circ 8 are more commonly called 8mg Betahistine Dihydrochloride, and are prescribed for Vertigo, Tinnitus and hearing loss.

    • 197 Martha Perry October 11, 2011 at 12:25 pm

      Thank you so much for your reply. Seeing my rheumatologist today and will chat with her about this. Have the best day you can!

    • 198 Martha Perry October 11, 2011 at 11:58 pm

      Saw my rheumatologist today. I have inflammatory arthritis as well as fibro/CFS. We spoke of the circ 8 but she did not think it was available in US and mentioned that ginger can help with balance issues. I love it when I can try a natural approach. I tried it many many years ago and it caused acid indigestion but this time I will try it with food. And there are many ways to get ginger into my diet. Here’s hoping! Martha

  125. 199 Mechelle October 12, 2011 at 9:42 am

    Good for you Martha, I am all for the natural approach too, rather than taking tablets for tablets sake like i am doing at the moment. I see my neurologist on 27th so i am hoping that he may change me meds to stop me having to compensate all the strange side effects with other tablets to be honest :o) Have a good day x

  126. 200 Marie October 19, 2011 at 1:15 pm

    Hi everyone. I’ve got nerve damage/compressed nerves left over from radiation treatment to my groin and pelvis, and in the last couple of weeks the pain has been so bad I can’t walk more than a few steps.
    Over-the-counter painkillers don’t touch it, even codeine, so my doc has put me on Amitriptyline. She didn’t explain that it takes time to work, but just said to start with 10mg then after a couple of nights increase to 20mg, then 30mg. I only took the first 10mg dose five nights ago, and had 30mg last night, but the pain hasn’t decreased yet.
    How long does it usually take?? Should I be building up more slowly?
    At the same time however, I haven’t noticed any of the side effects… yet.
    Do they take a bit if time to kick in too?


  127. 201 Davina October 21, 2011 at 7:56 am

    My daughter of 27 yrs had a spell of labyrinthitis in May this year. Two weeks later she was using her applemac laptop in dim light. When she switched it off, she expericened a light flash, which left her blinded with white light for about 30 secs. From next day our lives have changed. Started having very odd severe headaches. Together with headaches she has been expriencing visual disturbances. She could hardly keep her eyes open, unable to watch TV, use computer or read. Everything she sees is pulsating, her whole vision has shimmering lights. Has developed lots of floaters. She complains of pressure behind her eyes, one eye has become puffy.
    We have had countless visits to the opthomolgist. She has had her eyes dilated 4 times and apart from slight variation in her Optic nerve ( which they are not worried about) has found nothing wrong. Neurologist has prescribed her 10mg amitripyline for 2 weeks increasing to 20 mg. She has also had VEP test which we are awaiting results. Has been taking amitripyline for 2weeks now , headaches are better, however visual disturbances are still there day and night since May.
    This all happened in the middle of her postgraduate exams. Earlier, in the year she had also injured both her knees on a gym machine while preparing for charity runs. We are extremely worried for her future because for someone who was so active to become dependant. Would like to know if anyone else has experienced any of this. Any help would be appreciated.

  128. 202 Agi October 22, 2011 at 12:01 pm

    Unfortunately I am experiencing very bad side effects, headaches, dizziness, sleepiness, reduced visual field, nausea, tingling numbness in the face, inability to focus and have to search for words and it also prevents me from sleeping, I am in a weird state of being asleep during the day and not being fully asleep at night, as if the two states are being washed into one. I also sing and this seems to effect the way my vocal ways behave. I have 3 young kids and need to drive so I will have to come off. I have taken the lowest dosage, 10mg, I have been prescribed it for chronic back pain. I have started 4 days ago, I also have a PhD to finish, this kind of experimentation is not for me.

  129. 203 Carol October 28, 2011 at 4:53 am

    I fell and broke both wrists 5 years ago. They were pretty damaged, and the Drs. put in titanium implants. Have been on Gabapentin for a long time, but that isn’t doing much for the ongoing pain. My Dr. suggested Ami. but I have been afraid to take it. This website has been helpful.

  130. 204 Rosa November 4, 2011 at 8:29 pm

    Hi Everyone, im so pleased ive found this site 🙂
    Im currently taking 50mg of Amitriptyline for Cervical pain, due to Lazer Surgery in 2007, my doctor thinks its Nerve Damage, im also taking Prozac, i had a scan 2 weeks ago & get the results on the 15th Nov, my Specialist says if my Scan doesnt show anything up i will have to take Amitriptyline for the rest of my life, Im 46, Ive put over a stone on in weight & everyday i feel Groggy & really tired, tonight ive been having alot of pain, im just pulling my hair out!! Ive been on Amitriptyline since August, Has anyone else had Cervical pain????

    • 205 Michelle Johnston November 28, 2011 at 8:24 pm

      Hi Rosa, I have nerve dame from a C Section in 2001 and I can totally understand how you must be feeling. I am on ami 20mg since Aug 2011 and it does help a bit and help you sleep at night. Big hugs xx

    • 206 kate gebhardt February 9, 2012 at 7:14 am

      Hi Rosa, I was on Prozac and Dr prescribed ami for sciatica – but he said I had to wean off Prozac first as the 2 drugs are contraindicated. I have done this and it’s been tough, weaning off prozac is hard enough bit then weaning on to Ami… wow. Could it be that the pain killing effect isn’t working because you;re on the 2 drugs which are not compatible together? Perhaps check with your pharmacist or another Dr to be on the safe side. Good luck, Kate

  131. 207 martha robey November 5, 2011 at 11:40 pm

    does anyone have nerve pain in both legs?

    • 208 Michelle Johnston November 28, 2011 at 8:26 pm

      Hi I have nerve pain in my right leg from nerve dame from a c section. Try it it does help you sleep and sleep is a great healer. xx

  132. 209 clare eagles November 11, 2011 at 8:10 pm

    i have been diagnosed with fybromyalgia just today. I had a baby 4 and 1/2 mths ago and since then the pain in my back, knees, ankles has been horrendous.
    My doctor has prescribed me Amitriptyline tablets 10mg. I have read the main blog and some of the comments on here and i just hope i am receptive to them. Wish me luck.
    Clare xx

    • 210 Michelle Johnston November 28, 2011 at 8:28 pm

      Hi Clare, Sorry to hear about your pain, I have nerve damage from a c section, ami does help you sleep at night and does help to block the pain.
      If you had a c section I suggest you talk to a lawyer as you may have damage caused by the surgeon. I am suing mine at the mo. Best of luck xx

  133. 211 julie November 16, 2011 at 8:15 am

    It has been so good reading all about this drug, but has anyone tried it for severe tinnitus thankyou,,,,

  134. 213 carole November 16, 2011 at 9:09 pm

    iv been taking amitriptyline for 5 nights now after the first2 nights the headaches were 100% better but i felt tired out and weak all the next day so went back on to 10 mg but the headaches came back so iv taken 2 tonight ,just dont like the tired feeling and heavy legs the next day ,any one else felt like this .

    • 214 Sandi November 28, 2011 at 8:01 pm

      I hated it. Took it for 3 days and felt as if I was held down to the bed by magnets, which made the pain across my shoulders much worse the following day. By the 3rd day my heart rate was 120 beats per min, and stayed at that all day – went to an emergency appointment with the GP and she took me off it. Think I would rather have the pain! I just want something to help . . . . . . started acupuncture last Friday, so we’ll see.

  135. 215 Avril Brown December 4, 2011 at 3:54 pm

    I have just found this site today and reading all your comments has been so useful. Following a second hip operation two years ago my pain never improved despite physio, etc., (After my first hip was done I had no pain at all for 7 years). This time I still had the pain and was unable to sleep for more than an hour and a half at night followed by continual waking in pain every half hour or so. Three months ago my GP started me on 10mgs of Amitriptyline at night and immediately I began to get longer and better sleep. After MRIs,etc., my GP referred me to the the pain clinic where the consultant told me I have neural pathway pain which once “switched on” can’t be reversed. He increased the Ami to 25mgs plus two co-codamol at night. That was three weeks ago. I am still getting a much better night’s sleep.
    I thought the Ami was only to help me sleep, and was surprised to learn on this site that it also helps with pain and the analgesic effect is supposed to last during the day – that wasn’t explained to me. My pain returns as soon as I get up and walk around, so it doesn’t last for me! So far the side effects aren’t too bad. Yes, mouth is drier but not badly so, and I don’t feel too groggy in the mornings. Maybe I am just lucky, or maybe after a time side effects will develop. My main worry is weight gain because I am unable to walk for long distances. I hate taking medication and won’t take pain killers during the day, which I have been prescribed to do. I hate the thought of getting addicted and having to take Ami for ever, and I might suggest to my GP that I go back to 10 or 20mgs of Ami and see if I still get a good night’s sleep. I realise from reading this site that I am not taking a high dose, but would like to cut it down.
    Thank you to everyone for their comments.
    Best wishes to you all.

    • 216 Nancy Ross February 8, 2012 at 12:34 am

      Find out if you have a water arobics class in a pool around you the water lets you do things you can t possibly do on dry land

  136. 217 cheryle December 6, 2011 at 4:23 pm


    I have stumbled gratefully on this blog after returning from seeing a chronic pain specialist.

    I have been suffering severe pain to my left side and for over a year now. First of all they thought it was due to a very large renal cyst, but this has now been removed surgically and unfortunately the pain has remained, if not worsened.

    They now believe that the cyst has damaged my nerves and I am being referred for an epidural, hopefully within six weeks.

    Up until now, I have been “controlling” the pain with, buscapone, diazapam, codiene and tramadol. However, recently the pain had become so bad, that I admitted myself to hospital to receive morphine.. Opiates are not my preferred method of pain control and for two reasons, 1, the constipation exasperates the pain and 2, I’m an ex heroin addict..

    My Dr has recommended Am (I’m not going to pretend to spell it), which I was reluctant to consider, mainly for the stigma attached, however, after reading this page, I am seriously considering this option.

    I hope that everyone manages to remain pain free…

  137. 218 Mechelle December 12, 2011 at 3:41 pm

    Last night i decided NOT to take my Amytriptylene 10mg that i have been taking along with one 250mg of Naproxen since July… I had ended up gaining 12lbs, using a mouth gel for dry mouth, artificial tears every day for dry eyes, a heightened sense of smell and virtually no feeling …ahem…down below if you know what i mean! Last night was pretty tough, hot sweats and felt likes waves of nausea but i feel okay at the moment…am going to try and see if i can at least get the excess weight off, as i gained 36lb when i originally got injured, and then lost 19lb before july when i went on the Amy… Have not told my Doctors, naughty, i know, but they just wont listen… And i know in my heart of hearts that it must be the tablets, as i have not changed my eating habits or excercise. Hope everyone is well x

  138. 219 lindsey wharam December 22, 2011 at 10:16 pm

    Am looking for some advice son 13yrs deafblind/cerebral palsy has been diagnosed with neuropathic pain it is horrendous to watch. Has been on Amitriptyline 25mgs at night 3 weeks ago with minimal effect. Have a brilliant paedriatrician who has said up the dose to 25mgs x day and diazepam, choral hydrate and midazolam if he gets desparate—–or me!! Any thoughts please.

    • 220 Martha Perry January 5, 2012 at 10:04 pm

      As a nurse (disabled now) who was nationally certified in pain management who is not a chronic pain pt due to autoimmune and other diseases the best advice I can give you for your son is to bring him to a pain clinic. I see a doc at MGH in Boston who is wonderful and has helped me more than any other specialist. Pain management is a specialty field. I hope and will pray for relief for your son and peace for you.

  139. 221 Susie January 30, 2012 at 7:57 pm

    Oh what a fantastic blog, I’ve been looking for help with chronic headaches on the web for weeks. It’s taken 3 months for the doctor and neurologist to agree and I’m now on 20mg of Amitriptyline. It’s taken the edge off it and I’m trying to go back to work as a teacher this week. Has anyone else had problems with light sensitivity? A friend noticed that my pupils were more dilated than everyone elses today but I’m not sure how long that has been the case and even if that could be the cause of the headaches and migraines. The optomitrist and doctor haven’t mentioned it but maybe because unless your next to someone else you wouldn’t notice it??

    Dry mouth has been a problem since I started taking it at 10mg and I had to drink constantly today as obviously my job requires a lot of talking. I suppose this will be a long term and should invest in another drinking bottle to leave at school.

    Does everyone else manage to get back into work OK? I’m trying to anticipate any problems that might arise.

  140. 222 Nancy Ross February 8, 2012 at 12:30 am

    I broke my back in October nasty fall off a horse and my Dr just gave me the pills 25mg . I will be sure to take at 9pm so i can get my aching body up.
    I have been doing phyiso every week and have been going to the swimming pool its the only time that I can really move and I love it so i hope that weight gain business skips me
    I was just put on long term disability which in away gave me the reality check I needed to stop trying to push my Recovery time let the healing continue and hope this drug is the answer

  141. 223 kate gebhardt February 9, 2012 at 7:24 am

    I have just started ami 25 per night and seeing some improvement in my sciatic pain. However I had to come off my prozac to start the ami because the 2 are contraindicated. Although my depression is pretty well under control, I am worried that if I put on weight with endep I may get depressed again. Can anyone please tell me, has anyone NOT put on weight on ami??? Several people have mentioned weight gain, I’m hoping sometimes weight stays stable? I know it’s kind of a shallow issue but I’m sensitive to it.
    Thanks so much, Kate

  142. 224 elise February 23, 2012 at 2:10 am

    Just discovered this blog. I have been taking amitriptylin (sp?!!) since 1998 when I developed severe bilateral plantar fasciitis. At the time it helped slightly with the pain during the day, but it let me sleep at night.

    after I got over the plantar fasciitis, I continued to take this bec it let me sleep through hubby’s snoring! I have not gained any weight from it and my only side affect is that I sleep a solid 9 hours so if I want to wake up for work I can’t take it too late at night. If anything it helped me maintain a healthy weight bec I sleep at night and then have the energy to exercise during the day.

    2 years ago I upped dosage to 20mg as the 10mg no longer seemed to be working as well

    now having tremendous foot pain after an injury – the amitriptylin continues to help me sleep but does not seem to do much for the day pain. however, after reading this I’m going to try upping dosage to 30 and see if that makes a difference.

  143. 225 Sara February 28, 2012 at 8:00 pm

    Hi, I’m just about to start on Amitriptyline because I’m getting cronic tension headaches so I have been prescribed a low dose 10mg for a week to increase to 20mg. Obviously the side effects and the fact it is an anti-depresant is scaring me. I’ve also been told I cant drive for a little while and operate heavy machinery but this is part of my uni course so I’m a little worried that these tablets will affect me. Being at uni and only 20 I go out at least once a week and saw that I shouldnt drink with these tablets.
    I just want some advice of how people have found this medication and if you can actually drink?

  144. 226 Jan April 7, 2012 at 11:50 pm

    I was reading through your blog posts and saw this one on amitryptaline. I had just read a paper written by several doctors in Los Angeles about substituting CoQ10 instead. It is dealing more with the combination of cyclic vomiting and migraines, but it is very interesting.

    In my family we were able to cure three generations of migraine sufferers by taking methylfolate or extra folic acid. If you have one MTHFR gene mutation you can usually get by with bumping folic acid supplements up to about 800mg a day, but if you have two mutations, then you can’t convert into folic acid into folate and you have to use the form that is already converted.

    Love your blog!

  145. 227 maya April 11, 2012 at 3:46 pm

    I have piriformis syndrom, and after many months of pain, have just been given ami to help, as I have terrible hip pain from the sciatic nerve. I love walking and going to the gym,and I’m so sad that I cant anymore, due to the awful burning pain. (my dog is also depressed, and missing his walks!-lol). has anyone any advice on how to get relief from piriformis?, and Has anymone else had sciatic relief from this pill.
    Is it true that it will cause weight gain? i am only on 10mg, so I’m hoping not, as I need to keep my weight down for other health reasons.

  146. 231 Kay April 18, 2012 at 9:47 pm

    Have just taken first dose of amitriptyline I am hoping for some sleep and a break from constant nerve pain caused by a bulging disc. I need to get up for work in the morning and hope this won’t be an issue! The comments on here have been a help, thanks, and I hope all of you have less pain soon, it really drags you down.

    • 232 eveline April 26, 2012 at 4:31 pm

      I took 25mg of ‘Amy’ last night for the first time for some pain relief and some sleep. I did not get any pain relief, and therefore not much sleep. Dry mouth was not too severe. Will try again tonight.

      • 233 Susie April 26, 2012 at 6:49 pm

        It takes a while to work, between 4 and 6 weeks. My headaches are only now unoticable after taking it for 3 months. The dry mouth is awful but it’s still better than chronic pain.

        • 234 Arlene Sherwood June 24, 2012 at 6:15 pm

          I just started last night on Ami, and was hoping it would work sooner. I have Chronic Neuropathy Pain from an old Thorocotomy Surgery.Have constant pain.Wondering what kind of Pain Meds to take with this as I do not think it is going to help my pain..I do have Norco and Valium,but they do not work.Anyone else have this kind of pain,and if so,what do you take that helps Nerve Damage.Have it 24 hours a day…NON STOP!!! Thanks for any info…Arlene in Oregon

          • 235 michelle johnston June 26, 2012 at 8:23 pm

            Hi Arlene, Ami does help but I know how you feel, as I had an emergency c section in 2001 which has given me long term nerve damage and it has really affected my life, I now have Severe Chronic Fatigue (used to be called ME) as well. Don’t know how much your dosage is I started on 10mg at night, helped a bit. Now on 50mg’s that seems to have helped heaps BUT I still have days where its there 24/7. Sadly there is no cure for nerve damage and our brains just keep the loop of pain going. Its a living hell isn’t it? My nerve damage wasn’t diagnosed till 2009. I personally think that if I had been diagnosed earlier my life would have been better, as the brain, emotions, fatigue etc would have only been short term. I take 2 x co-codamol 50/300 4 times a day and morphine when required BUT its our brains that keep sending the pain signals. It is a vicious circle. Tried cognitative therapy and have had nerve blocks none of this has helped. We are all individuals and what works for one person won’t necessarily help another. Excuse my spellings. Its just nice to know we are not alone, there are millions of us suffering in silence, all of us looking for a solution to take that nasty evil pain away. Sorry I don’t have the answer but I do understand. Much love Michelle x

            • 236 Arlene Sherwood June 26, 2012 at 8:48 pm

              Thanks for the post Michelle…I sure don’t suffer “in silence”.:) I have been in pain for 13 years ever since botched surgeries.My pain NEVER stops and I have had just about every test you can imagine.We have had to go Bankrupt twice since 1999 and will probably lose my home of 42 years if I have to go to many more Doctors.They say I may have Crohnes or IBS but really do not know.I am 75 and my stomach looks like I am 9 months preg..It never goes down and the raw sore pressure pushes constantly.The doctor just gave me Amitriptyline 3 days ago,but it makes it push harder,but am going to stay on it a few more days..I take Norco and Valium,but it also makes it push harder..Will keep reading this board.It is great.Thanks hun…Love Arlene in Oregon

              • 237 michelle johnston June 26, 2012 at 9:06 pm

                Hi, Give ami a try I am on 50mg at night, has really helped with the pain, you will find hopefully that you have to take less painkillers.I still have days when the pain just won’t shut up BUT you may find it helps you more x

              • 238 michelle johnston June 26, 2012 at 9:16 pm

                Hi Arlene, what I mean by suffering in silence is that when I first had it I used to scream the house down. All that does is give me a sore throat. Drs only see you for 10 mins then get on with their lives. We have to live with the affects of surgeons decisions/ bodge ups and its so unfair. No one understands me either only other pain sufferers. I’ve had mine for nearly 11 years I am an old person at 42 the thought of living with this pain forever does my head in BUT what can I do, what can any of us do? That’s the sad bit, we suffer and no one can cure us. It takes me 3 hours to get up in the morning get dressed etc and then I am so exhausted its back to bed. Some life hey! I keep going for my husband and 10 year old. I have no life. Please try the ami it does help me and I am sure it will help you too. All my love Michelle x U.K.

                • 239 Arlene Sherwood June 26, 2012 at 10:48 pm

                  Hi Michelle,
                  Thanks again for the post.What town do you live in?You just said the UK.
                  I am going to stick with this Amitriplyne for a few anyway.Got to give it a chance.Can’t tell in just a few days.I am so disabled and sore it hurts me to dress.I only go to Doctors.I can’t shop or go anywhere else as I am on Oxygen and it is so clumsey,or I am.My hubby is 75 also,and his legs hurt but he won’t go to the Doctor.He still works or we would lose our home.It has went down so much in Appraisal,but still high payment.Until later.Love Arlene:)

                  • 240 michelle johnston June 28, 2012 at 8:07 pm

                    Hi Arlene, I live in Stony Stratford, which is a very old medieval town near Milton Keynes in the UK. Sorry for the delay I was really ill yesterday and was i bed all day and have dragged myself downstairs this evening to check my emails and spend sometime with my family. Hope the amitriptilyne gives you some relief soon. Love Michelle x

                    • 241 michelle johnston June 28, 2012 at 8:12 pm

                      P.S. I ‘m like you rarely go out, except to drs or hospital etc. I tell everyone not to take the little things for granted. I miss walking so much and swimming and cooking and shopping. Could go on all night anyway, nice to know someone else who really understands, makes you feel less alone. Good knows how people used to cope pre TV, computers, online shopping etc.(they must have died of boredom LOL) Love and hugs Michelle x

                    • 242 Arlene Sherwood June 28, 2012 at 9:04 pm

                      Hi Michelle and thanks again for the post. Yes ,it is good to talk with someone that understands Chronic Pain.This Amitriptyline has not helped me so far.Does nothing for my pain,and I take the Norco and Valium,and all it does is numb the pain pressure a little,but the Docs have tried everything else.I think Predisone could help me,but am more afraid of the side effects..None of the drugs they have give me for pain have even helped at all.I gave Neurontin a try twice over the years,but no help…Hun,am sorry I forgot,what you are diagnosed with.Is it Fibro? Good memory here 🙂 Think I am losing some of that too.It is so nice to hear from you.Love Arlene

                    • 243 michelle johnston June 29, 2012 at 11:09 am

                      Hi Arlene, I have nerve damage from an emergency c section in 2001. Was not diagnosed with nerve damage till 2009, went through all sorts of hospital departments and had several investigative surgery things done. I am in the process of taking the hospital to court. Hopefully I will get some recompense so I can help my daughter have a good future. I would just like the surgeon to say sorry. Fat chance hey? Keep trying the ami, what dosage are you on? Sounds to me like you are on a low dose. You have to play around with the dosage to get it right. I’ve been on it just over a year. It does help, but my bodys is just exhausted from all the years of pain. Have Chronic fatigue as well, which is horrible. Like I say you may need to talk to the health professional who prescribed it and get them to up the dosage. Lots of Love Michelle x

                    • 244 Arlene Sherwood June 29, 2012 at 1:44 pm

                      It was a Gastro Doctor that gave me the 10 mg Amitriptlyne.That strength just is not helping me much.I think I will ask if I can take 20 mg but am afraid of side effects,but am so tired of pain.I don’t want to take the Norco and Valium as it is hopeless.I NEVER lose my Chronic Pain.Even hurts me to type on these keys.I just have NO LIFE except Face Book.I just love it.Are you on Face Book?I have a Group on there called THE INVISIBLE ILLNESS,for people with all kinds of health issues.If you are on Face Book,look me up under Arlene Sizemore Sherwood.
                      Love Arlene

                    • 245 michelle johnston June 29, 2012 at 3:18 pm

                      Hi Arlene, I know what none stop pain feels like matey, I definetly think you should try upping the dose, obviously best to check against what other meds your are taking with your dr. I have got a FB account haven’t been on it for ages BUT I’ll have a nose at your group sounds interesting. Take Care Michelle x

                    • 246 Susie June 29, 2012 at 4:50 pm

                      I’ve been on amitripyline 50mg for chronic migraines and have been on this dosage for about 6 months now. It took a few months for the pain to come under control but it did. Now I have the problem of poor memory, bad concentration and no energy. I’ve had to give up work as a teacher because half the time I couldn’t remmber what I was teaching or I was walking around looking ‘spaaced out’, according to my head teacher. Hopefully the stress levels will go down and then I can get off the tablets. 10mg Arelne doesn’t sound enough to do anything, it took 30mgs before I noticed any difference at all.

                    • 247 Arlene Sherwood June 29, 2012 at 5:36 pm

                      Thank you Susie,for the answer.I did ask my Doc if I can take 20mg as 10 is not helping my Chronic Pain.I don’t even know if this drug is good for nerve damage..Will keep posting..Arlene in Oregon:)

                    • 248 Arlene Sherwood June 30, 2012 at 2:04 pm

                      Michelle,The Doc did tell me to take 20mg if I wanted to,but it did not help my cronic pain at all.Seemed to just make it push harder.Guess I will try it one more night.I am going to stick with my Probiots also in case I have IBS.

                    • 249 Arlene Sherwood July 1, 2012 at 2:53 pm

                      Well,this is my second day of increasing my Ami to 20 Mg,and I can tell very little difference than 10 mg.Guess I better try it for a few more days. Can’t really tell anything on just 4 or 5 days..

                    • 250 michelle johnston July 1, 2012 at 4:56 pm

                      Hi Arlene, I know it is easy to say give it a couple of weeks to really kick in but please try it for a bit longer. I know we are all different. I just feel so sorry for you, as I know how stressed pain makes me. Sorry its taken me a few days to reply. Just give it a bit longer you’ve had to live with the pain for so many years like me just say okay lets try if it doesn’t work then at least you can say you gave it your best shot. Is it not even helping you sleep better? Have you noticed any other changes how ever small. Try keeping a diary and make notes of how you’ve found it. Severe Stomache aches/ IBS is nasty I find I have days where my stomache is bloated too. Opiates and pain relief meds can really affect the system. I’m like it this weekend too. I try to avoid certain foods that make it worse and use lactalose to try and make it easier to go to the toilet. Being blocked up is horrible. Not a nice subject to talk about, but its part of human nature :0) and if I can help just a tiny bit in making you feel better I will. Have you tried a hot water bottle, that can be really soothing, the stomache muscles get really twisted up and the more stressed/frustrated you get the worse the pain will be. I know this from my own problems with chronic pain. Have you tried acupuncture or anything like that, some people respond really well to acupuncture. If I can think of anything else I will email you. Still haven’t been on your FB page. Just remember you are not alone that gives me great comfort. Also makes me angry as well because I don’t like to think of others suffering too like me.
                      Lots of love Michelle x

                    • 251 Arlene Sherwood July 1, 2012 at 8:49 pm

                      Thanks for the post Michelle…Yes hun,have had accupunture and the whole ten yards..I don’t think I have heart problems,even though sometimes the PAIN make my blood pressure higher and then I read where Ami may be bad for heart problems..
                      Hun,why don’t you “friend” me (Arlene Sizemore Sherwood) ,on Face book and then go to my Illness Group,and way toward the bottom posts I put my history.Maybe you have some of the same..Only if you feel like it.I spend all my time on there.Love Arlene:)

                    • 252 Arlene Sherwood July 2, 2012 at 4:24 pm


                    • 253 michelle johnston July 2, 2012 at 7:44 pm

                      Hi Arlene, You poor thing you really need to see your doctor. You need to be checked out properly to make sure there is nothing serious going on internally. Let me know how you get on. Stay strong. Big hugs Michelle x

                    • 254 Susie July 1, 2012 at 5:00 pm

                      You need to use it for between 4 to 6 weeks before you’ll notice any difference. It works accumulatively.

                    • 255 Arlene Sherwood June 30, 2012 at 1:53 pm

                      My Doctor told me to increase my Amitriptyline to 20 mg last night.I did.I slept normally ,as I always do,but my raw sore pushing pressure pain under my ribs are just pushing harder and more sore.Wonder if I should stay on the 20 mg.I just feel as though my huge stomach is going to burst..

    • 256 Donna thomson. April 29, 2012 at 10:00 am

      Hi Kay, how are you getting on with It now? I am considering this drug for the same problem. Thanks

  147. 257 eveline April 25, 2012 at 7:15 pm

    For those of you like myself who suffers from chronic migraines, have you tried Botox injections. I have been having 150 units of Botox every 3 months for 3 years now and it has been quite effective. I am at least 80% migraine-free. Secondly, I have been given a script today for amitriptyline 25mg to be taken at night for pain in my leg (knee) bursitis of the pes anserine, and this was caused because I went for a walk as part of my fitness regime. Normally I ride the bike but because all felt well with my knees(I have OA in both knees)I made the mistake to walk. The exact same diagnosis was made last year because of a walk. I am apprehensive to try this drug due to the weight issue. I need to lose weight to take off some stress off the knees, so it is like a double-edged sword, just like having to lose weight but I am limited in what I can do because of ‘bad knees’. I haven’t slept for more than a couple of hours in the past 8 nights due to severe pain down my leg to my foot, this is exacerbated x100 at night. Dilaudid did not help. I am in my mid-forties but “they” say I am too young for a partial knee replacement. Had another x-ray today. Still fighting with the GP’s. I want quality of life in my forties not in my seventies (regarding knee replacement). Cortisone injections are ineffective and damaging to any surrounding tissue. For those on ‘amy’ does it cause your appetite to increase or does it just put on weight because of blood sugar etc. because if it is only appetite increase, then a lock on the fridge will work. lol however, if it just puts on the weight without putting the increased food in your mouth, then again I am falling on the double-edged sword. I wish they would find the cause to the pain, rather than treat the pain and “seeya later”
    I wish all of you better health.

  148. 258 Beate April 28, 2012 at 6:16 pm

    I am so happy I found this website. People around me doesn’t seem to understand that my pain is cronic and ‘advice’ me not to ‘stuff myself with drugs’ although the doctor has prescripted them, so what a relief to see that I am not the only one with dreadful pain that keeps me awake night after night. I tried 10 mg amitriptyline last summer but went off again after a month as it didn’t help a bit although it did help me sleep. Now I wonder if 10 mg was too little. I still have the rest of the box so I will try again and then go up to 20. But what about the long term effect. Most who wrote were just starting on amitriptyline – how is it today? Will I have to go from 10 to 20 to 50 mg, maybe higher, to get any effect as I understand that the body get used to them? The pain is cronic so I need more than a few months relief, probably the rest of my life, but I am really scared about being addicted – probably because of all the ‘friendly’ warnings.

    • 259 elise June 26, 2012 at 5:35 pm

      I was on 10 mg for 12 years and then needed to increase dosage to 20mg, and have now been on 20 mg for several years. so if I need to increase my 10 mg every 12 years, I think that isn’t too bad!!I take it mainly to help me sleep – it has been a huge help in that regard, less helpful for pain management but since sleeping is part of healing it indirectly helps me there as well.

    • 261 michelle johnston June 26, 2012 at 9:17 pm

      Hi, Give ami a try I am on 50mg at night, has really helped with the pain, you will find hopefully that you have to take less painkillers.I still have days when the pain just won’t shut up BUT you may find it helps you more x

  149. 262 lorraine toon April 30, 2012 at 10:06 am

    I find your comment very useful I’m in a lot of pain due to nerve pain. I take amlytrialine at 50mlg. I still have pain but I get a good nights sleep

  150. 263 Mary May 1, 2012 at 11:42 am

    I have had ME for 10 years (well, finally diagnosed 10 years ago after many years of being unwell), and about a year and a half ago, to add to the already myriad amount of symptoms I had, my upper back/shoulder area on the left side became painful and stiff. I tried osteopathy (helped, but expensive to keep up), acupuncture (no change), tramadol, (great, but addictive and only took when very very bad) and normal ibuprofen (mild relief, but can’t take long-term), and finally in desperation, took the advice of a GP who started me on amitriptyline. I had been reluctant to take another antidepressant as I am on another one for depression and sleep problems. I started a month or so ago on 10 mg of amitrip and it initially helped, but the pain started to come back. Yesterday I decided to try 20mg and I am pain-free today. Let’s hope it continues at this dose as if I have to increase the dose again, and start experiencing the dry mouth, I will have to stop as the dry mouth will adversely affect my precarious dental situation.

  151. 264 Sarah May 8, 2012 at 9:29 am

    I have suffered from Chronic Tension Headache for twenty years. I am 42 years old now and I can’t remember when I was last headache free. I can still function with my headaches, I work full time, but I was starting to get really fed up with having them. Six weeks ago I decided to talk to my GP about my hedaches. Firstly I was given Naproxen which is an anti-inflammatory, these tablets didn’t touch my headache. I have been on amitriptyline 10 mg for one month now, my headaches have reduced to about 50%(pain measurement) but they are still hanging around everyday. My dose has now been increased to 20mg for another month. So far I haven’t noticed any side affects. I take my tablets at 7pm and I can easily get up at 6am for work. I will post again in another month to let you know if my headcahes are improving.

    • 265 Karen November 10, 2012 at 8:53 pm

      Hi Sarah. Just wondered how you are doing. My story is similar to yours: I am 45 and have experienced chronic headaches/migraines since my early 20s. I had occasional headaches as a child but they started to become a problem after I had qualified as a nurse and then suffered frequent headaches. I think this was due to shiftwork, irregular meals and stress, also bruxism (teeth grinding) also due to stress. I used to take codydramol as it waseasy to get hold of on the ward. After I left hospital nursing I took paracetamol and Ibuprofen instead. Over the next 20 years or so a pattern developed of moderate daily headaches, often with up to 4 doses of OTC pain medication, frequently with no effect. Even though I am a nurse I hadn’t been aware that these meds could cause rebound headaches. I had tried coming off the pill, cutting out caffeine and red wine and I spent a fortune on cranial osteopathy, which seemed to help in the short term but not in the long term. Pregnancies were particularly hard as I could not take painkillers. After searching the net a few years or so ago I realised that I was compounding the problem with regular painkillers and read that Amitriptyline can help. It took me a couple of years to go to my GP about it. I think I was worried that they might not take me seriously but eventually I went and was referred to a headache clinic. The doctor I saw knew exactly what I was talking about, said that her daughter suffered as well and that she would write to my GP. I started off on 10mg and at first it really knocked me out and I was going to bed really early but that wore off. I upped the dose to 20mg and like a lot of people have said found that taking it about 12hours before I get up is the ideal time. I also have a large glass of wine each evening and always sleep extremely well but without any grogginess in the morning. Having been on 20mg for about 6months I have just increased to 25 having found that the occasional headache I experienced has become much more frequent: daily for the last week and paracetamol/Ibuprofen not very effective. I think I will try Feminax now for ‘breakthrough’ pain (this is the same as but cheaper than migraine medication) but have no qualms about increasing the Ami dose. After daily headaches for over 20 years, now being pretty much pain free has improved my quality of life no end and I would urge anyone to try it.The drowsiness should wear off as you become used to it and I have experienced no other side effects ( Ihave put on a bit of weight but I think thatt’s down to too much cake!!) Good luck to you with your own story.


      • 266 Sarah March 25, 2013 at 4:45 pm

        Hi Karen

        Thank you for your reply, I am pleased that you are doing ok on the ami. After posting last May I took 20 mg for about a month, then I decided to come off it as I felt I wasn’t making much progress. I started having some neck and shoulder massages and I had some stretches to do along with watching my posture. Although the massage and stretches were very nice, I suffered with continuous headache up to and including Christmas.
        I continued to go to work, socialize etc, but had this constant tightness and concrete block feeling in my head and shoulders.

        I returned to the GP in Jan 2013, I started on 10mg of ami for 4 weeks, then 20mg for 6 weeks. I still have a headache, but I feel brighter in myself. I have just been put onto 30mg for the next 4 weeks and if I see no improvement I will go back to the GP as she says there are other things we can try. I am sleeping really well and so far haven’t gained any weight, but I do watch what I eat. I would say my headaches are improved 50%, but I would love to be pain free. Today I was ready to give up (again) and just live with the pain, However you reply has motivated me to stay with it and try to resolve my head pain. I will mail again around 1st May to let you know if 30mg has done the trick. I have been taking two paracetamol along side the ami for a few days over the last week and this has seemed effective. How many weeks did it take for you to be pain free? I have read a research article that says improvement was continuous for 26 weeks
        Best wishes, Sarah

        • 267 Sarah April 19, 2013 at 2:24 pm

          Dear everyone

          After taking 10 then 20 mgs of amitriptyline I would say I felt 50% better with my tension headaches, that is they are there all the time but with 50% less intensity. I sleep well through the night without waking up with a headache during the night. I returned to the docs and was increased to 30 mgs at the beginning of April. It is now April 19th and I have struggled to take 30mg for more than two days in a row as it left me feeling a bit rough. Again it would have been easy to throw the towel in as we all want to be pain free (or our idea of what this is like). However I have decided to continue. I am still taking 20 mg and on some days I don’t think I have a headache, on other days I definitely have a headache, but I feel overall there is a good improvement. I feel the pain is originating in my upper back and shoulders, I am doing regular stretches for this. Also I have never had a migraine and I feel lucky that I can still work, shop etc with my type of headache even though it is wearing and tiring. I read back the research article that said on a dose of 30 – 50 mg amitriptyline improvement was continuous for 6 months from the beginning of taking the tablets ( you could say optimum dose for the person). Therefore I have decided to continue and will probably increase to 30 mg in June if not before. I will continue then until Christmas to give everything a fair assessment. Like everyone on this site I am worried about weight gain and side effects. So far I haven’t gained weight and I seem to get over the dry mouth after a week or two. If I have to increase to 50mgs and I have a better quality of life then this is ok too. For me I am trying to be as positive as I can about my headaches and the treatment I am taking. Also, if I want a glass of wine, maybe 2 but no more with a meal this has also been fine. I take my tablets at 6.30-7pm and get up at 6.30 am for work. Good luck to everyone, I will post again when I have some news.

  152. 268 Rowena May 8, 2012 at 11:38 am

    I am taking amitriptyline for cronic lower back pain due to degenerative discs and have also had my dose upped since I have had severe pain in my chest and upper abdomen- possibly from a hiatus hernia, I notice on this post a lot of people are taking it for migraines, I suffered really badly from migraines until I found feverfew (a plant) I took 2 tablets a day and I have not had a migraine since (about 3 years) migraines are horrid and I got quite depressed at one point as I thought I would never be able to live normally- I don’t suggest you stop taking prescribed medication but I do suggest that if you suffer from migraines then feverfew is a great preventative (always better than cure) it takes a few weeks to really get into your system.
    On a different note I have started itching all over my body- no rash or marks (apart from the ones left by my itching) but it’s all over my body, feet, hands, back, everywhere, does anyone know what that may be? I am currently taking tramadol, amitriptyline, domperidone, lansoprazole and paracetamol…… can anyone help?

  153. 269 Joyce May 25, 2012 at 5:26 pm

    Can you take a low dosage amiyriptyline 10mg for pain with starting on celexa for depression. It did help my disc in back pain.thanks

  154. 270 MIaLondon May 28, 2012 at 7:37 pm

    Dear all,

    Iam so happy I came across this blog,because its my first night tonight to start Amitriptyline.
    I have Marfans Syndrome,and would be absolutely amazing to hear from someone with same disorder.
    Iam 27 years old,and had 5 major surgery’s on my spine,ribs,chest and heart.
    I suffer from extremely chronicle pain in my lower back,legs and head.
    These pains started about 5 years ago,but became uncontrollable.
    Pain starts slowly in my lower back and spreads to my legs and my head,it could last for 24hrs and no pain relief will help.
    I usually end up in A&E because my heart starts to panic and get out of control.Even though after many scans and tests they still cant see anything and for me as always no diagnosis.
    I could go a week or a month with no pain at all,but when it hits me,hits me hard.
    I would love to hear from someone with similar pains or even maby condition.
    Iam starting on a dose of 10mg tonight and will increase it to 20mg after 7 days.
    Iam also on Wafarin due to my mechanical valve and plenty of beta blockers to control my chronicle AF.
    I will see in few months how Amitriptyline will effect and work for me.
    I wish you well and THANK YOU for all info its super helpful.

  155. 271 Emily timms June 15, 2012 at 6:24 pm

    Hi I’ve been given amitriptyline to try and help with my tension headache as I’m in a lot of pain and nothing seems to be working. Getting enough exercise/water ect but I’m just worried about the effect it mite have on me as I have 2 children. It’s only 10mg one to be taken at nite but it’s my first time ever being on anything like this.

  156. 272 Laura June 16, 2012 at 9:30 pm

    This post has really been helpfull to me as inam just starting these meds and have been very apprehensive. I feel more comfortable to give them a try now. Thank you

  157. 273 steve June 26, 2012 at 9:02 pm

    Hi,I’ve just started taking 75mg each night 4 spondilosis pain and am so pleased with the pain relief ,dry mouth not very nice ,but much better than constant pain ,prior to this I was on gabapentin , but the pain came back after taking max dosage for 2 years

  158. 274 Sue June 28, 2012 at 3:46 pm

    This post has also been helpful to me. Am starting on ami for the first time tonight on 10mg for the pain in my jaw. The thing that worries me is that it says it can cause ringing in the ears (tinnitus) and as I already get that wouldn’t want it to get any worse. Anyone else experienced ear problems.

    • 275 Sue June 28, 2012 at 3:46 pm

      This post has also been helpful to me. Am starting on ami for the first time tonight on 10mg for the pain in my jaw. The thing that worries me is that it says it can cause ringing in the ears (tinnitus) and as I already get that wouldn’t want it to get any worse. Anyone else experienced ear problems.

  159. 276 Amanda July 5, 2012 at 2:54 pm

    Hi everyone,
    I’m so glad ive found this link. I have been given Amitriptyline for chronic pain in my stomache and pelvis after finding that I have adhesions after having a total abdominal hyserectomy 4 months ago. I was told to start on 10mg and increase slowly. Ive been on the medication for 3 weeks now and am currently taking 35mg at night but find that I am still having to take co codamol 30/500 aswell during the day because of the pain. I am feeling very down because of the pain and don’t know what to do with myself. I work at a Gp’s surgery and had only been back at work 2 weeks then have been off again since because of the pain. I feel that nobody takes my pain seriously and feel also that work are pressurising me into going back to work even though I am still in an awful lot of pain. Has anybody else been in similar situation and if so how did you cope with it?

  160. 277 Angie Lees July 8, 2012 at 9:16 pm


  161. 278 John July 23, 2012 at 2:09 pm

    I had an atypical angina like pain. The Doctor prescribed low dose Amytriptyline, “pain goes away, it’s not heart”. It has gone away on 10mg.
    The lightheadedness is a worry with machinery and cars, so I am stopping. If the, not very severe, heart pain comes back I will put up with it knowing it is safe, as the lesser of two evils.

  162. 279 Sinan Bayram July 29, 2012 at 10:34 pm

    Thanks heaps, I’ve had pretty much identical results as you for.chronic back pain. Thank you for your story!

  163. 280 Jacqueline July 31, 2012 at 4:28 pm

    I’m just trying Amitriptyline for muscle pain, has anyone found it helped for fatigue etc?(I hope so!)

    I have no diagnosis but Fibromyalgia has been mentioned, though I don’t have those painful pressure points I keep reading about, but a lot of other symptoms fit.

    • 281 Elise September 22, 2012 at 1:45 am

      If you have a lot of muscular skeletal pain and a lot of symptoms of fibromyalgia, but don’t have the painful pressure points, you should rule out ehlers-danlos syndrome, hypermobility (check the website).. A lot of the symptoms are similar, but the pressure points don’t apply to EDS

  164. 283 Mary Schmidt August 29, 2012 at 2:21 am

    I am 70 years old and have had chronic pain from advanced osteo-arthritis, spinal joints for 42 years. I have a spondylolisthesis L. 4-5 and a dislocation of C.7. Several months ago, my doctor put me on Amitriptyline with a starting dose of 10 mgs which I took at bedtime. Nothing happened for 10 days but on day 11, I noticed a lessening of the deep ache in my thoracic vertebrae which was the first real chronic pain relief I have ever had. I continued on 10mgs for another week with no further benefit so the dose was upped to 20 mgs. and after a week, I had the lowest level of chronic pain that I have had in decades! I am now taking 25 mgs. daily to see if the level of pain can be further lowered and to find out what the optimum dose for me will eventually be. The only side-effect I’ve had is a dry mouth which is nothing compared to the pain relief I have now got. I have no hesitation in recommending this drug to people who share the same condition as mine. At the very least, it is well worth trying.

  165. 284 Olivia September 1, 2012 at 6:06 am

    I started Amitriptylin in October of last year as treatment for Daily extreme migraines, that completely were ruining my life. I was involved in a rollover motor vehicle accident two and a half years Ago which gave me a severe concussion among other things. A few months after that is when the migraines began, and it was severe migraines 6+ times a week, with a pain level over 8+. I have a very high pain tolerance, and as a young person(I am 22 now) it was destroying my education and work life as I was not able to concentrate or go about my daily business… I was constantly in extreme pain and sick from them. I tried many different medications with multiple doctors and had no
    Success. I was finally put on low dosage Amitriptilyn, 20 mg which I take at night. This medication has literally been a miracle in my life. Since starting it 11 months ago, I have had a total of 7 migraines. It’s a completely new experience for me, after over a year and a half I a severely reduced enjoyment of life. My doctor also prescribed me Axert, which I take when I feel a breakthrough migraine or severe headache beginning. I take one Axert, and the migraine is gone within half an hour. I am extremely grateful I was finally prescribed this amazing medication. It may not be for everyone, but it truly changed my life.

  166. 285 Dr (Mrs) Deborah Dore September 7, 2012 at 11:15 am

    Early days for me yet.Been on them for 5 days. I feel really drowsy already! And already some relief from pain too. I am very sensitive to drugs. I take 34 meds aday.

  167. 286 David Palmer September 17, 2012 at 3:15 pm

    I have hip pain from a bad groin hernia repair and back pain, I am not able to take OTC medicines due to a pronlem with my stomach so I was pleased to hear of Amitripyline.

    I started on 10mg and moved up to 25mg, the latter was awful, I was like a walking zombie. 10mg makes me very tired, I forget what I am supposed to be doing and makes working in a responsive way impossible.

    It has not really helped except that it knocks me out so I can’t get any work done. On reading this blog I will try and take it earlier in the evening and see if that helps.

  168. 287 Sue Packham September 28, 2012 at 12:04 pm

    Hi everyone
    I’m a newbie to,this site. Been diagnosed with ME in February this year having been ill for a year beforehand. My life has altered radically in these 18 months. I’ve gone from being a gym loving, hyperactive woman in her fifties who ran her won business, travelled the world trekked, walked, lived life to the full, to being currently bed bound for last 7 weeks. I have had to close my business after 18 years, my partner left 5 weeks ago as he could no longer accept the limitations the illness placed on our lives, i can longer look after myself, so,am staying with family.

    My reason for writing is to add to all my troubles I’m being driven made with neuropathy pain and have been prescribed with ami 10 mg and this site has been amazing to read as I was too scared to take them as I thought they were anti depressants. Since becoming Ill I hardly sleep, some nights not at all and some nights just 2 hours so I’m hoping that the ami will help with the pain and insomnia. These sites are a life line when all,you have to,look at are the same 4 walls week after week. I’m going to start the ami tonight and I’m already worried about taking it.

    Any encouragement or a cyber hug would be much appreciated

    Sue, Kent, uk

    • 288 Michelle February 11, 2013 at 7:36 pm

      Dear Sue, Sending you a very big hug and oodles of love. i can empathise very much with what you are going through, your life sounds very similar to mine. Don’t be afraid of ami, stick with the first 2 to 3 weeks, they are the worst. i so hope you feel better soon.
      I live in Milton Keynes by the way in the UK.

    • 289 Jacqueline February 11, 2013 at 8:06 pm

      Sue, your experience sounds tough, a big cyber hug sent your way! I hope you feel better.
      I found Amitriptyline a little hard with side effects for the first couple of weeks but it does wear off to unnoticeable, I think it does help with pain, even if it’s those extra couple of hours of sleep I think my body needs.
      The dose is a lot lower than antidepressant level and since being on it and talking to friends I’ve found quiet a few people have been prescribed it for pain!

    • 290 Beate May 24, 2013 at 7:07 pm

      Hi Sue,
      I know how you feel from neuropathy pain it is terrible. I was on a combination of Tramadol and Triptyline for years, then saw a different neurolog who changed the Tramadol to Gabapentin. Good to see a different doctor. The combination af 3 x 300 mg Gabapentin and down from 25 mg to just 10 mg Triptyline for the night is taking the pain.


  169. 291 angie vee October 8, 2012 at 6:16 pm

    Im grateful to read all these messages as Ive just been given amitriptyline 10mg (but was told to take up to 30mg if needed) for awful arm/shoulder pain which wakes me up every night, so spend nights in pain, and am then shattered all day. also have back and hip pain. Reading the leaflet in the meds packet terrified me re side effects etc, but seeing all your comments has made me much more positive to try it. Can I ask – has anyone taken is as a short term measure only? It seems reading comments that if it works for you – you are on it forever? For now, if it means I get to sleep at night – Ill tale that as a major breakthrough!

  170. 292 rachel October 12, 2012 at 7:46 pm

    I’m 69 had headaches and nausea for 9 years tried everything and spent a fortune on alternative stuff, feel depressed and sometimes suicidal as you can’t do anything except lie down when pain is bad – any suggestions?

  171. 293 Caroline October 22, 2012 at 11:24 pm

    I started taking amitriptyline last week for my pain and was just googling how it works and other people’s experiences when I came across this. It’s reassuring, so thank you very much.

  172. 294 lynda[stargazer]harwood November 26, 2012 at 10:52 pm

    hi everyone, so glad to have found this link. i have a herniated disc in my back and waiting for an op.i have severe pain plus constant pins and needles.Ive had bad reactions to most meds.ive been on amitriptyline for a week and the pain is side effects except a tingly mouth.

  173. 295 Elizabeth January 16, 2013 at 3:25 am

    So enlightening to read all the comments. I was prescribed 10 mg amy by my dentist because I suffered for 2 years with burning tounge syndrome. This feels like a nerve pain and was so painful as to be becoming debilitating. it took about 3 months till i felt the burning tounge was subsiding. other benfits were a feeling of well being each day. and almost as importanat I am sleeping much better – going right back to sleep when I wake. If anyone you know is suffering from this burning tounge syndrom, please recommend this to them. I am 84 and have much shoulder pain (no diagnoiss) just injections, so have just gone back on the amy to try to help that pain. will take it forever if it helps .

  174. 296 Sonia February 5, 2013 at 7:05 am

    Hi just a question I have been on ami for 3 months for migraine and have been upping my doses from 10 to 25 and now to 50 my migraines have been less frequent but nothing more, and I have gained a bit of weight.

    My question is this of everyone that has had success on this drug do you drink coffee as I have read this can interfere with the drug

    Also is it ok to drink decaf tea/coffee?

    • 297 Susie February 10, 2013 at 4:22 pm

      Hi, I’ve been on ami now for just over a year, 50g every evening. I can’t drink coffee of any type as it gives me aweful headaches as does chocolate ( a massive loss to my life). I can drink decaf tea and boy do I drink a lot of that but you might want to research it because most brands of decaf tea use chemicals to take out the caffine that are thought to be carcenagenics. I use Clipper decaf and love it but it is difficult to get hold of (use the internet) although a Sainburys near me sells it.
      I am now just beginning to get back to something resembling normal after giving up my job as a Primary teacher, it was too draining and I couldn’t cope with the lighting. I have joined a gym and enjoying low impact excercising again. Good luck.

      • 298 Susan February 11, 2013 at 6:01 pm

        I have been taking amitriptilyne for over 2 years for migrain, I managed on 20mg for a year then had to up to 50mg for it to carry on working, I am now on 60 to 70 a night the reason i sometimes take 60mg and sometimes take 70mg is because my migrains started with the menapause and so when my skin starts inching and i get very hot my face gets red I use 70mg because i know that is when my migains get the strongest. I take 50mg Sumatriptan at start of migrain and anti sickness cyclizine. No ami doesn’t take every migrain away but i couldn’t function with out it. The only side affect i get is it makes me tired in the morning and if I take it to late it’s very difficult to get up to early, as i don’t work out side the house it’s not a problem. i am the only driver though and with a dissabled husband and son with autisum I make sure we allway have what we need in the house incase I can’t drive and my daughter still living at home . I had incressed migrains befor christmas 2012 due to the stress of my mother being very ill and passing away 10 days befor christmas. I took extra ami to be able to cope with them but also to make sure I wouldn’t have a migrain at a critical time like the weekend my fammily and were in hospital befor my died and helping with the following arangments, I am lucky enough to have 11 brothers and sisters to help.

      • 299 Sonia February 11, 2013 at 6:55 pm

        Hi susie

        Thanks for your response I have already been drinking decaf tea and had no idea about the chemicals I will definitely switch. I do not have coffee as a trigger but I wondered if it could be blocking me feeling the full effects of the amitriptyline. I’m with you on the chocolate and also cheese. I will have to do trial and go coffee free for a while to see if it makes a difference.

        Thanks sonia

        • 300 Jacqueline February 11, 2013 at 8:33 pm

          I don’t see a difference with caffeine, but then I only have a big cup of coffee in the morning and that’s generally it. I do notice more pain if I drink alcohol, I’m not sure if that’s due to the interaction or the lack of quality sleep. I take Ami for insomnia, fatigue and muscle pain…or what’s been diagnosed as CFS. (but I’m not so sure on the diagnosis)

  175. 302 Anne Wright February 5, 2013 at 7:23 pm

    I have been on Amitriptilyne for about 21/2 years for Vulvodynia. Take 10mg and this has worked for me from the beginning, with only the very occasional day with slight discomfort. I do have a glass of wine with it and haven’t noticed a problem. Like other people it made me drowsy in the mornings. If I need to get up especially early I make sure i take the tablet around 6.00 to be safe- as I have to drive to get where I’m going. I have found that if going out for the evening I can now skip an occasional dose, or I take it when I get home and have get up later.

    Have, unfortunately, now developed Burning Mouth Syndrome – another ‘mystery’ condition – how lucky I am! I think ‘they’ (medical profession) have decided that this is called Vulvostomatodynia as I guess they have to call it something even if they haven’t a clue what to do about it.This at the moment is HORRENDOUS and have nothing to ease it. Am going to try upping the dose of Amitriptyline to 20mg to see how I get on. Under these circumstances, I think alcohol is off the menu and will definitely take the tablets early in the evening.

    Keep your fingers crossed that it works.

  176. 303 Holly February 13, 2013 at 10:17 pm

    I’ve been taking amitriptyline for 4 weeks, first at 10mg and now at 20mg taken at night.

    After 7 months of undiagnosed chronic abdominal pain, I am very pleased with the level of pain relief I get from amitriptyline! I still do get breakthrough pain throughout the day, but my day to day level of pain is so manageable that I am now able to return to work. So I’m delighted with the improvement in my quality of life after just 4 weeks taking these tablets! It also means that a can significantly reduce the amount of paracetamol and tramadol I need to take throughout the day.

    I would highly recommend that people give it a go, if their doctor suggests it as a treatment.

  177. 304 Carolyn February 15, 2013 at 7:08 pm

    Hi I have been on 10mg Amitriptyline for 5 years for neck pain. I have tried to wean myself off several times but went back on them because the side effects were too awful. The reason I want to come off is because I am getting too many side effects. Now I am trying again I am doing it very slowly with a pill cutter. I am taking 3 quarters of the 10mg pill for a month and weaning off slowly that way month by month. I am monitoring the side effects every day and I have been getting them. I cannot emphasize the dangers of these drugs, you must wean off slowly.

  178. 305 Braylene Goode February 15, 2013 at 11:58 pm

    I am going off of Amitriptyline slowly and the only withdrawal symptons I have are of being really itchy. And I have to take an antihistamine to relieve the itch. It’s like I have all these allergies that I have never had before. Does anyone know if this will last long?

  179. 306 sue March 5, 2013 at 9:46 am

    Hi, I have recently developed severe muscular types of spasm pain that comes and goes. I can feel it there threatening most of the time and I know if i move an arm to far it will go into spasm and often I awake in the night in dreadful pain and it can last up to half an hour. I also seem to be getting a similar pain in my legs and even stomach. I have been in hospital and have had loads of tests. I will be getting my MRI of brain and neck result this Friday. I am assuming they would have contacted me if there was anything seriously wrong as I had it 6 weeks ago! Although you can never tell. The doctors seemed puzzled with my symptoms and I felt a fraud. (But when a muscle spasms in my arm, I can hardly bear it). I have cervical spondylosis (which is sort of general wear and tear). I have also suffered many visual disturbances a day which are the classic migraine auras minus the severe headache. I am worried sick. The doctor put me on to 300mg of Gabapentin 3 times daily, but I’m wondereing if Amitripyline might be the answer. Also does this sound like Fibromyalgia to anyone out there. Please help me.

  180. 307 Katy March 18, 2013 at 6:10 pm

    All these comments have been really helpful to me as I have just started taking Amitriptyline – 10mg at night.(for neuropathic pain) the 1st dose left me groggy most of the following day, the 2nd and 3rd doses left me slightly less groggy and dizzy in the mornings. I have tried various other medications but most of them have left me with horrendous side-effects. So I am hoping that a bit of perserverance with Amitriptyline might pay off. Heres hoping . . . . .

  181. 308 Really06 April 24, 2013 at 12:50 am

    I have just taken my first dose of Amitripyline 10mg tonight. I am 38 years old and waiting for tests to confirm if I have MS. The pain in my body is so bad, I went to the ER as I couldn’t even walk. I am worried after reading these posts that getting off the meds is hard? If so, I won’t be taking one tomorrow and I will learn to live with the pain until they figure out what is going on….

  182. 309 Julia on Dartmoor May 17, 2013 at 10:22 pm

    I have just started on 10mg at night, tonight being my second. This morning I slept through the alarm! My lower back pain has been waking me up so often that I would get up feeling like I had not been to sleep. Ami seems to help with the sleep and pain already. Rubber feel to mouth is no big deal. Could do without putting on weight, is this common? Have been helped by everyone’s comment to take it earlier, thank you. Assuming I will feel more with it first thing as time goes by? A very helpful site.

  183. 310 Julie November 18, 2014 at 11:05 pm

    I started using 100mg/night almost 15 years ago. It’s been the same dose all that time. It’s stopped chronic insomnia from a blow to the head as a young kid, and although the migraines still occur (aura), sensitivity to light and sound plus the lopsided feeling of the head completely ceased. It wasn’t pain, it was really like being a dumb blond… while being blond!! Having a consistent brain, good sleep, it made a big difference. Verapamil is the cohort daily. The single daily dose with long acting caused eye jitter for 7 years (if the initial physical symptoms are pretty severe, it is very difficult to tell what is from a med and what is from the body/brain). The docs didn’t investigate it until it affected care to a new born. It was switched to two/day in standard form. That made functioning normal. Using both has been a Godsend, well worth the search for something that worked.

  184. 311 Iris Ferreira July 22, 2015 at 8:32 pm

    My experience with chronic pain in my neck and shoulders was getting so unbearable I did no know what to do. Physiotherapy would bring relief for about three weeks, and even then I had to be careful with pushing or lifting the lightest of items at home. Just mopping a room lightly or using a Hoover for a short space of time would soon after leave me in great agony. Doctor put me on one month’s trial with amitriptyline 10mg. Yes for the first week I found your mouth would be unusually dry for a short period, waking up was a bit of fuzzy new feeling in the mornings, as it took a while to shake up and slowly awake and get on with the day. For me, there was never a trial period as the pain , four months later in my shoulders and back have never been back. If I feel I have over extended myself , my body starts to tell me to take it easy. 10mg has been good for me taken at almost the same time every evening. I hope this will help other suffering from chronic pain especially in the neck and shoulders . I am pain free with 10 mg amitriptyline daily

  185. 312 Carol Yates December 21, 2015 at 3:54 pm

    I know that this is old news but maybe other people can be helped re the dry mouth problem and Amitriptyline. I use a mouthwash from Bioteine which is especially for dry mouth. Some chemists stock it, including the larger Boots stores but I get it online fromChemist Direct or Amazon.
    It’s a bit pricey but does work
    I currently use 40mg Ami to help with my MS symptoms at night and have gained a LOT of weight. After being size 10 for most of my adult life it’s a shock to the system having to buy size 16. So am on the hunt for an alternative!

  186. 313 Cheryl September 27, 2016 at 1:58 am

    I am taking this medication now, I think I’ve been on this a few weeks now.. First dose was 20mg, once every evening. I have sciatica and I’m into 10 months now. I’m in pain all day and night! I was up until 4-5am trying to sleep!
    These pills help me sleep better, pain is somewhat less.. But I adapted fast to my medication. Now I am on 50mg.. Not noticing a difference ..should I try 75 next?
    I was also prescribed something else but wasn’t given consultation for it, so I need to go back and ask lol but I’m scared to take it with these. My mouth is so dry! It’s so gross hahaha. I am going back to physio sometime soon and it’ll be my first time going with these pills so I hope I see improvement!
    It takes so much out of me!
    I cry so much, often on the floor lol. I have 2 little ones at home & they need mommy but I’m limited on what I can do.
    I haven’t walked with my kids outside in 10 months ….& I love the outdoors lol even a grocery trip is brutal on me. But we do what we need to do 🙂 even if I’m crawling on the floor to clean, or doing laundry bent over lol. It gets done!

  187. 314 Elaine Green February 15, 2017 at 11:49 pm

    Thanks for the info. I also take this medication for degenerative disc and sciatica and am finding similar effects with 30mg dose but 20mg was not enough to knock out the pain. After reading your post I am going to try taking them earlier in the evening.

  1. 1 Huh? I’m a Pain Meds Weirdo « ChronicallyMe Trackback on November 8, 2009 at 5:55 pm
  2. 2 Alternative Low Dose Anti-Depressants to Amitriptyline « ChronicallyMe Trackback on June 1, 2011 at 9:35 am

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Push It 11 Sep 2011

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