Amitriptyline For Pain Relief

I’ve been taking low dose amitriptyline for over a month now for chronic pain and migraine relief.

Briefly I have had (so far) success with it.  I’m doing a blog post about my experience in the hope it may help others considering trying it.

For me a 20mg dose taken at night has offered excellent day to day relief from migraines, pre-migraine head (feeling light headed and sickly) and for chronic pain like stiffness in my neck and shoulders.

I find with my ME/CFS/CFIDS the low dose is not quite enough to prevent pain and migraine when I do more than usual.  If I overdo it even slightly the pain quickly tips past my blanked out point.  But I find it beneficial all the same and day to day have been using just a fraction of over the counter pain killers and prescribed migraine medication.

I take the amitriptyline at night to avoid the worst of the sedative type effect.  If I have to get up in the night to use the toilet I feel a bit like I am walking through treacle.

I started on a 10mg dose (I think this is the lowest dose you can take).  The relief was just as effective for me as with 20mg but I found it started to wear off around 6-7 hours before the next dose was due (late afternoon and evening for me).  20mg has proven to me the optimum dose for me personally.

I did take my nightly dose up to 30mg under my doctors direction but found the side effects too bad to handle.  I suffered with drowsiness during the day time, constantly feeling like I was ready to sleep.  I also had many headaches and a terrible stiffness in my neck which felt very solid and even worse than the pain I have with no medication at all!  Also I suffered with a constant dry mouth and throat, a sensation not soothed by drinking water or anything else.  The inside of my mouth and back of my throat started to feel like rubber after a week.  I drank lots of fluids (being constantly thirsty) but it didn’t help and just made me need many trips to the toilet!

Now I’m back down to 20mg those effects have gone.  I still feel a little drowsy in the earlier part of the morning but it does not interfere badly with my usual routine.  I also still have a dry mouth but this is only usually very bad 30-60 minutes after taking the tablets.  I also get terrible dry eyes but this is only overnight and does not persist the next day.

The pain relief lasts the whole of the next day up until a couple of hours before my next dose is due.

Everyone is different and people with ME/CFS/CFIDS can be very sensitive to medications.  I have yet to review my findings with my doctor – who knows she may want me to try a bigger dose for longer to see if the side effects persist!

I was highly sceptical about taking a tri-cylic or any kind of anti-depressant for pain relief and was worried it would send out the wrong signals about my condition.  The dosage is too low to have an anti-depressant effect and if people are misinformed I guess it’s up to me to put them straight :-)  

Although it is still early days on this medication, personally I have found amitriptyline to be a useful  and effective preventative treatment for chronic migraines and pre-migraine feelings, as well as for low level chronic pain.

53 Responses to “Amitriptyline For Pain Relief”


  1. 1 Jacqueline L. Jones July 25, 2007 at 6:03 pm

    Amitriptyline did not work for me. I am very reactive to prescription and most herbal medications. Magnesium and grape seed extract or pine bark extract have worked wonders for my pain.

    I have added your blog to my blogroll. Your candor is helpful for people with chronic pain and fatigue who may not realize that someone else feels the same way.

  2. 2 Deejay November 15, 2007 at 3:36 am

    I have chronic muscle pain which didn’t respond to analgetics (NSAID). My doctor put me on Amitriptyline (20 mg at night), at the same time started taking Formula 303 (Valerian root, Passionflower and Mg) and the pain is almost gone. I do get some pain in the late afternoon or evening before taking my next dose.

  3. 3 Sara January 19, 2008 at 2:19 am

    I have suffered from chronic pain in my shoulders for about two years now and no one has been able to diagnose the problem. Luckily, one doctor suggested I try 10 mg. of Amitriptyline. I have been on it for almost 2 weeks and I feel tremendously better. I can function well, and my mind is no longer thinking about my aching shoulders. I take it before bedtime and I am also sleeping much better than usual. If I take it too late, (after 10:30 at night) I have a really hard time getting up, so I try to remember to take it earlier in the evening. Around the same time I started to take this medication, I also started exercising and dieting. I have been walking on a treadmill 6 days a week for the last 2 weeks. I started at 1 mile and I am now up to 3 miles. Also, I started to really watch what I eat, as I want to lose 10 lbs. But I haven’t lost any weight at all. I am wondering if anyone else has had weight gain or the inability to lose weight while on such a low dose.

  4. 4 rachelcreative January 19, 2008 at 11:07 am

    Hi Sara. I’ve read that weight gain is very common with amitriptyline but the research is about people on higher doses. But I suppose whatever the reason people gain weight on it could stay be present even a low dose.

    I read that it can effect your blood sugar – maybe that has something to do with it.

    Here’s hoping it’s just a false start to your great efforts for losing a bit of weight.

    If you are concerned or it gets to be a problem talk to your doctor – there are other tricylics that can be prescribed which have good pain relieving effect on a low dose but which have less side effects.

    And thanks for your comment :)

  5. 5 ashysheela October 9, 2008 at 5:14 pm

    Went to see my specialist today (primiarily to get a report to support my DLA appeal) but he is suggesting “treatment options” to my doctor for my headaches and head/back/neck/jaw tension/pains, first on the list is amitriptyline so i may be joining you on it soon – it’s reassuring to go back and read your experience… anything to add after being on it so long?

  6. 6 rachelcreative October 9, 2008 at 6:19 pm

    Only that I am still happy taking it :o )

    It makes me very thirsty, it numbs my tongue if I don’t swallow the tablets straight away and the cat seems very interested in it so I have a panic most nights about dropping a tablet and the cat guzzling it down.

    It doesn’t stop all my pain, my aches and my headaches/migraines. It’s like it stops pain andmigraines to a certain level and if I psuh beyond that level it’s like a switch has been flipped and all the pain comes flooding in. BUT I do get that pain relief to a certain level which is good and a lot better than taking tonnes of paracetomal and codeine.

    It doesn’t help my sleep. It does nothing for mood (being a very low dose anyway). But it’s made my migraine medication an average of 6-10 tablets a month instead of that 30 or more I was taking (and still getting migraines) before amitriptyline.

    The most difficult things about it is learning to spell it ;o)

    Oh! I read on forums some people not being able to tolerate it at all. I would say it took me about 6-8 weeks for it to settle fully. I felt like it had settled after 4 weeks but actually it was helping me sleep (making me dozey) up until about 6-8 weeks of taking it.

  7. 7 ashysheela October 9, 2008 at 6:41 pm

    It is hard to spell, i was cutting and pasting it after the search engine said “do you mean ami…”!

    I am hoping it does help with sleep too, but should not get hopes up (as usual!).

    The thirsty thing is a bit worrying as i am always thirsty as it is! My poor bladder is so over-worked…

    I kind of wish they would not always reach to give us pills as the first solution, but i suppose if i am not in pain i will not alter my posture/tense up in reaction to it and that may help ease the problem, whatever the cause is…

    Well, i will see what my doctor thinks (if anything – won’t hold my breath for her to engage with the problem just because the specialist told her to!)…

    Thanks for your feedback – it seems less scary than i had heard in terms of side effects etc. Will just have to see how i tolerate it… i am enough of a zombie as it is so hope i take it well!

    Does your cat like licorice? apparently amitripyline (think that is right!) tastes of it? ;)

  8. 8 rachelcreative October 10, 2008 at 8:07 am

    Can’t say my amitriptyline tastes of licorice. It only makes me thirsty about 20 minutes after I’ve taken it for a while, not for 24 hours. I too am always thirsty (before the meds) drink like a fish and pee like a racehorse ;o)

    I read some really nasty side effects too. It did make me quite woozy and a bit zombie the first week and the first week I upped my dosage. I couldn’t handle 30mg as i was too spaced out so went back to 20mg which is what I am still on now.

    I would say (I forgot this bit) that sometimes I have problems with peeing. Sometimes it’s like retention and sometimes I get sudden urges to wee and have to make a dash for the loo. But it’s not every day and day – it’s time to time and for the large part manageable. The pain relief is kind of worth it.

  9. 9 ashysheela October 10, 2008 at 9:26 am

    ok, well will see how it goes! Think it will take a couple of weeks for the doctor to get the specialist’s recomendations, so won’t be starting right away… thanks for all the info :)

  10. 10 Janis October 31, 2008 at 10:59 pm

    Hi Ladies,

    thank you for your info it is interesting. I started experiencing chronic and acute head aches which put me in hospital and the prescription of high doses of codeine and Tramadol and Stematil. This week unhappy about this my GP suggested Amatriptyline. I have been on 10mg for about 8 days and so far so good. Not had a flair up of the Migraine. Sleep is better and leg pain reduced although still a problem in the night. Bladder sensitive as you describe.

    i have also been taking Sinutab for a few days because of pain and heat and inflamed sinus, and I am generally feeling a lot better. If I could bottle todays energy level I could be more hopeful of being able to go back to training.

    Wish you well
    Janis

  11. 11 rachelcreative November 1, 2008 at 9:18 am

    Hello Janis

    Great news that your migraines and pain seem to be responding and (more) under control. Sounds like they were really awful. How wonderful to have some relief! Long may it continue.

  12. 12 LisaV December 8, 2008 at 4:57 pm

    Hello,
    Just to say thank you, I have found your blogs very useful. Ive just been prescribed 10mg amitriptaline for sciatica, and am doing some research before taking my first tablet. I was very poorly on both tramadol and codine (unable to function, urinary retention, vomiting!), but as I am in pain for seven and a half hours a day, I am having to consider other options. I will let you know how I go on. thanks again. LisaV

  13. 13 Adrian Stowe December 12, 2008 at 9:39 pm

    Hi,

    I take 150mg Amitriptyline for severe headaches and sleep disturbance due to a head injury. I started out on 10 or 20mg but didn’t really get any relief until it was over 100mg.

    It makes me crave carbohydrates after about an hour of taking, it’s pretty uncontrollable, although I’m a bit OCD thanks to the head injury and Ice-Cream is my current obsession. I’ve put on roughly 6 stone since the head injury and at least 3 stone is from the Amitriptyline.

    Really helps with the pain, probably more than the codeine I’m taking.

    When the headaches are really bad only the combination of the Ami, Codeine and Morphine give me any relief. Not every day though thank goodness.

    The dry mouth and throat is horrible, I haven’t found any way to stop that either. Waking up is the worst, mouth and throat are bone dry :-)

  14. 14 James January 3, 2009 at 11:21 pm

    I LOVE Anitriptyline !!! But I am way past 20mg !! Try 300mg that is only if your Dr. tells you to and your Pain is that bad, and for me it is, It puts you in a haze and it is vary hard to have to work or learn on or Drive or just about do anything but for me it works vary well and life without it is a BITCH. It puts the Pain on a even playing field, it brings it down to a place that you can deal with it. I all so have to take a pain killer with it. But for anyone thinking on taking a higher MG DO NOT DO IT WITH OUT 1ST talking to your DR. because it really slows you down.

    So all and all I think its Great, beats the Hell out of staying in all that Pain.

  15. 15 Tom Anderson January 5, 2009 at 2:06 pm

    Hi There,
    When a diagnosis of M.E/CFS was finally confirmed by a Neurologist 10 years ago ( originally diagnosed by a Chinese accupunturist as P.V.F.S )I was prescribed amytripetc. , but couldn’t tolerate the side effects , my G.P then tried another anti-depressant with the same results.Finally after 5 years tried Citalopram from the smallest dosage and gradually increased the dosage. Been on it since then.
    Omprazole for stomach etc., and thats it for medication.
    I started the Perrin Technique treatment two years ago and have had slow , steady improvement with many symptoms either clearing up or reducing to almost unnoticable..the first to go was the almost continual sore throats.Not walking 100 yards yet.
    My osteopath suggested d-Ribose just before Christmas ,hence reading your blog , so I’m going to give it a go.
    Take it easy,

    Tom

  16. 16 sachi February 2, 2009 at 12:08 am

    I have been taking Tramadol, Flexaril, Lexapro and not Amitrip… for abour 1 month. I was giving the Amtrip for sleep and relaxation while I sleep. The Lexipro for my Bi-Polar, and the Flexiril for the pain. You would think I would be a Zombie. No in fact I was thinking the Amtrip was no help at all till i read this blog.

    Lexipro 20mg Once a day
    Amtirp 40mg Once a night
    Flexiril 20mg (when needed)

    I know with out my lexipro my family all get flights to other parts of the world till i get back on it.
    But Th Amtrip makes my mouth dry etc. What i had not noticed is that I have not had one Head Ache till today. I for got to take all my meds last night. From what I have read here some of you use it to keep them at bay. I am thinking that is what has kept me Head Pain free for the past month. I will have to go back on it and keep better track.

    Now the other thing i have read is that it is sometimes used to help kids not wet the bed. My 11yr son still has issues with this but also suffers from bad Head aches. I am going to see about getting him on this a.s.a.p.

    I hesitate from calling them migraines though the pain is that bad. My whole family has the same pain in the brain (hehe) as My son and I do. I am looking forward now to talking with his Dr. to see if this may be a key to pain free childhood for him!

    Thanks so much for all the info!
    Sachiko.

    (ps I cant spell my way out of a paper bag!)

  17. 17 Zissy March 4, 2009 at 5:51 am

    I take it for pain as well but have to cut the pill in half or it makes me loopy for the next two days if I take a full dose. I’ve tried to explain this to my doctor and it’s probably because of the other meds that I take but I’m ignored. So I took it upon myself to cut the pill in half and I’m able to function the next day without pain and stay awake.

  18. 18 Leon March 6, 2009 at 11:16 pm

    My 74 year old father takes Amitriptyline for chronic forehead pain that resulted from nerve damage during retinal surgery over 10 years ago. While it is effective in mitigating the headache pain it has some bothersome side effects. He will experience some minor confusion, forgetfulness and slurred speech. Is this common or likely related to my dad’s age?

  19. 19 rachelcreative March 7, 2009 at 7:22 am

    I found a couple of useful pages which talk about side effects and contra-indidcations for amitriptyline

    http://www.netdoctor.co.uk/medicines/100000107.html

    http://www.migraines.org/treatment/amitrip.htm

    Leon this may be of interest:

    “Antidepressants may cause the amount of sodium in the blood to drop – a condition called hyponatraemia. This can cause symptoms such as drowsiness, confusion, muscle twitching or convulsions. Elderly people may be particularly susceptible to this effect. You should consult your doctor if you develop any of these symptoms while taking this medicine so that your blood sodium level can be checked if necessary.”

    Confusion is also listed as a general side effect.

    Best to check with a doctor.

  20. 20 Lochdog April 3, 2009 at 9:03 pm

    Thanks for blogging about this. I’m about to take my first 10mg of ami. Was in a car crash last year and am suffering from back pain 24/7. Had v bad side effects with Tramadol (codeine has no effect) so am going to try ami plus Diclofenac. I’m concerned about taking something which could be addictive, but chronic pain is affecting my life so much that needs must. I’ve heard about the dry mouth and would be interested to know what works best for folks, esp as a few have said that drinking doesn’t help.

  21. 21 rachelcreative April 4, 2009 at 4:29 pm

    I’m not aware that amitriptyline is addictive though codeine can be.

    Sorry to hear about your pain. Hope the medication can help. Chronic pain is so wearing.

    If you find any answers about dry mouth please let me know! I haven’t found a trick. Drinking doesn’t really get rid of the dry mouth thing.

    I read something recently about “artificial saliva”. Sounds horrible! I knew you could get artificial tears as eye drops but haven’t heard of artificial saliva before!

    I thought I might ask my dentist (if I can remember) for any advice next time I see her. A dry mouth can add to the risk of tooth decay apparently as you’re lacking saliva as a natural defence. As if we need that too!

    Off to search the web for artificial saliva ;)

  22. 23 ashysheela April 5, 2009 at 9:34 am

    i was on antidepressants for a while and while not really aware of my dry mouth most of the time, it did reduce my saliva and this lead to me having several fillings at my 6 monthly check up – a rate of tooth decay that was truly shocking. My dentist suggested a good mouth wash, though another said not to put “that stuff” anywhere near your mouth and to use saline, which i found quite unpleasant, but i believe both will help to prevent tooth decay.

  23. 24 rachelcreative April 5, 2009 at 11:11 am

    I also read that when you brush your teeth at night not to rinse your mouth out with water but just to spit. It might help to prevent tooth decay but it doesn’t do much for that dry mouth sensation (if anything it adds to it!).

  24. 25 ashysheela April 5, 2009 at 5:53 pm

    i read that too, but am not keen on minty chalky mouth all night!

  25. 26 Pat Bailey May 20, 2009 at 10:29 am

    I have been on Amitripyline now for a few weeks now and yes it makes you feel groggy the next day . I feel it does help me sleep better but the dry mouth and numb tongue and tingling lips are a bit concerning . I am determined to carry on with it for a while. When I first got the swollen tonge and tingling lips it made me look like I had had a stroke. !!!

    • 27 rachelcreative May 21, 2009 at 7:49 am

      Pat – what has helped me with the morning groggy feeling is to take the amitriptyline earlier in the evening. Take it about 10-12 hours before you want to wake. I’m so grateful another ME person gave me that tip – it has really helped.

  26. 28 Therese Colligan May 27, 2009 at 11:58 am

    I too am taking this drug, which has helped quite a bit, but my mornings are still very difficult. I feel like I’ve traded one evil for another some days. Any suggestions regarding difficulty waking up? I only take 10 mg.

    • 29 rachelcreative May 28, 2009 at 10:05 am

      Therese – as I said to Pat above … what has helped me with the morning groggy feeling is to take the amitriptyline earlier in the evening. Take it about 10-12 hours before you want to wake.

  27. 30 -T June 10, 2009 at 12:41 am

    I’ve been on amitriptyline for about 2 weeks and my headaches/migranes have pretty much disappeared. Its really kind of weird not to have a headache looming day in and day out. I’ve had them since I was a kid and I’m in my 30’s now. I was running out of OTC pain meds that would work on me. But now I rarely have to take anything for headaches. I feel quite lucky to have found this stuff. I take it during the day because if I take it at night, I have a hard time waking up. But I’ll take the groggyness over a migrane anyday!!

  28. 31 dr2becynthia June 10, 2009 at 4:46 am

    It was interesting to read all the comments regaarding the use amitriptyline for chronic pain. I am on my second round of treatment for chronic pain in my lower jaw, and my pain management doctor prescribed amitriptyline, and needless to say , I was a little skeptical. However, the pain is not so bad, and certainly not as severe. I’ve actually had some very good days. The first round consisted of Xanax, and I was still in pain. Side effects…dry mouth, yes!!! Weight gain…yes, but I know I just need to watch what I eat and exercise more.I will consider taking it earlier in the evening to avoid the sleepiness the next day. Thanks for sharing.

  29. 32 sheila July 1, 2009 at 1:41 pm

    Hi Folks

    I have been suffering from neck pain resulting from whiplash injury
    3 years ago. Also feel so tired all the time without refreshing sleep. My Doc. has put me on 10mg of amitriptiline and I am hoping
    that this will help me get better sleep. I am 74 but want to feel 47 again!!! I am in a singing group where we have to perform choreography and I don’t want to have to give up yet!
    Doc has put me on Amitriptiline 10mgs at night. I will keep you posted of improvement.

    Sheila
    Taunton
    Somerset UK

  30. 33 The Mazster July 1, 2009 at 8:22 pm

    i’d say amitriptyline is addictive. I’ve been on them for 12 yrs and can’t get off them – when i have tried i get bad effects like no sleep (and i mean NO sleep), feel sick, feel downright awful. I was on 150mg but down to 30 but thats as low as i can go without effects. I get headaches every day but i’d sonner that than no sleep. awful pills! Hate them.

  31. 34 Michael July 12, 2009 at 4:39 pm

    Been reading through the blogs and questions posed in them. I have taken it for three years at 20 mg per day at night. Mine was prescribed for migraine vertigo? Or at least that is what the MD called it. I get dizzy and fall if standing, completely wipes me out for two to three hours. It helped with the frequency of attacks.

    I am now on 50 mg for help with depression. Haven’t seen help with the pain side of the increased dosage, but it may be a pain over the threshold of what that dosage blocks.

    As far as other side effects such as dry mouth or beeing drowsy I take it at night so haven’t seen or felt that.

    Oh yeah, artificial saliva is available, my mother used it for years while battling cancer.

  32. 35 sophia September 16, 2009 at 3:48 am

    I suffer from arnold chiari malformation (herniated cerebellum) and suffer severe head and neck pain everyday for the last eight years my nuerologist recommends I take amitripyline 10mg. I got the prescription today should I be worried I have a 9 year son to care for but desperately need relief. Is this medicine going to affect me as a mom?

    • 36 rachelcreative September 18, 2009 at 5:23 pm

      My personal experience with amitriptyline proving effective for relief of pain and more than halving occurence of migraines – is that I’m able to do more with amitriptyline than without.

      But it doesn’t agree with everyone. And like the next comment says it can make you a bit groggy for the next 2-3 weeks while you adjust to the medication.

      I hope you find relief from the pain. Chiari Malformation is no joke! All the best.

  33. 37 Katty September 16, 2009 at 4:52 pm

    I was having daily migraines/headaches with visual disturbance and nausea. This went on for many years, I thought it was “normal” to be chugging the aspirin like I was. My husband encouraged me to go to the dr. My GP put me on 10mg of Amitriptyline. The first 2 weeks I was very groggy, sleeping a lot, it seemed intolerable, but I stuck with it and I’m glad I did. After that I got used to it and had no side effects. After awhile, it wouldn’t even make me tired at night. The headaches started to come back and I’ve since upped to 40mg a night, which seems to be working, zero headaches.

    I take it at 5pm, so that I’m not groggy in the morning. Keep in mind that every time you up the dose, it’ll take you a couple weeks to get used to the side effects. If I’m going out at night with friends, I’ll only take 20mg at 5pm, and then take the remaining 20mg when I get home. The slower you raise the dose, the less likely you are to experience side effects. Keep in mind there are some people who take 300mg of amitriptyline, and they’re not passed out all day.

    Over all, I’m very pleased with the drug. Yeah, sometimes I’m groggy, but it’s better than being debilitated all day with headaches and migraines. I’ve not noticed an appetite increase or weight gain, actually I’ve lost weight because now I’m not too sick to exercise. Occasionally I get dry mouth in the evening, but not too bad.

  34. 39 Loretta Gelinas September 30, 2009 at 5:24 pm

    Very interesting to read everyone’s comments. Don’tknow if you have heard of vulvodynia (I know, a funny name) but I have suffered with this for 3 years. It is irritation in the vulva, clitoris etc. The pain is different throughout the day. In the morning when I get up I feel swollen and then since I basically have to “sit on it” – it alternately feels chapped, raw, painful etc. but I am thankful it is not also itchy which apparently is also an effect. I’m 68 years old but my doctor says my pain is indicative of a 20-30 year old – perhaps because I’m still taking hormone replacement medications.

    I’ve tried everything suggested to get rid of this but to no avail. The specialist just put me on 25 mg. of amitriptline and I take it before bedtime. I’ve been taking it for 10 days but haven’t noticed any difference in the discomfort. My mouth is a little dry and I do start yawning about 8 o’clock at night. I’m hoping this medication will evenutally kick in as I think my next alternative is botox, although, I don’t know if this is something the specialist will agree with. When I go back December 17th, I’ll have to discuss this if there is no improvement.

    As mentioned, I’ve had this for over three years and didn’t even know it had a name until about 6 months ago. Very frustrating. I no longer wear underwear, cannot tolerate slacks or jeans. I went to the beach twice and immediately had to get my bathing suit off as I couldn’t stand it. Hope there’s an answer somewhere

    Loretta

  35. 41 Gerry October 8, 2009 at 11:29 am

    The best cure for “dry mouth” is sugar free gum. Also helps prevent tooth decay, must be sugar free though.

  36. 42 Prunchie October 8, 2009 at 7:45 pm

    I was prescribed Ami last week for a problem i’ve had for 15 – 20 years.My digestive system goes into spasm having passed a stool.I get hot flushes,sweats,sometimes with palpitations.I then get a burning sensation and my energy levels die.I’ve been visiting my doctor for a long time,always complaining with this.I took the prescribed dose of 20mgs at night.When I woke the next day I was shocked to realise I had slept for hours,I had a heavy head and felt a little disorentiated,however the discomfort had gone.I took the same the next night and woke again very late.I went to town and felt dopey all day and almost got a panic when driving home in traffic.I’m wondering if this is normal initially and do these side effects wear off.Also my doc said they were non addictive.I’m not so sure I believe him.I don’t trust doctors anymore as you can imagine.

    • 43 rachelcreative October 9, 2009 at 9:38 am

      It does seem to vary person to person and a lot will depend on the dosage.

      My GP advised to start taking it gradually. So I started on 10mg and went up to 20mg after I think 2 weeks.

      When I started taking it, and then after increasing the dose, I felt dopey and a bit disconnected for maybe a week. Then this started to lessen.

      So it might be worth sticking with it for a week or so before you see if those effects are temporary. It’s going to be difficult with having to drive. If you feel too dopey to drive you might need to find an alternative arrangement for a week? If you can.

      I once took amitriptyline for despression a long time ago at about 75mg 3 times a day and felt like a total space cadet for the first week. I could hardly function – it was like being very drunk all day long for the first few days.

      I now take my dose 10-12 hours before I want to wake up, rather than last thing at night. I used to feel a bit groggy for a few hours in the morning. Now I take it about 8pm and wake feeling brighter.

      Hope this helps a bit.

  37. 45 Mandy October 13, 2009 at 8:25 am

    Wow, these comments are very helpful. Just diagnosed Amy for my constant neck pain as it is now making me depressed. I was reluctant to take it but after reading some of the posts I’m going to start tonight.
    I’ll keep you posed. Thanks.

  38. 47 Karen October 14, 2009 at 8:02 am

    I take 50mg for chronic pain and depression (a result of the chronic pain). It works great for the depression, I feel like myself again. It has helped with the pain but not taken it fully away. For about 4 weeks when i first started I was so drowsy I felt like I was drunk. I had alot of difficulty following conversations and getting out of bed. But then it really kicked in and I now get up at 6 in the morning before my alarm! It’s really given me my life back. I still get dry mouth especially at night and I feel warmer than I used to. I no longer wear long sleeved tops
    under my work gear. All things I am happy to trade for the depression and pain. I take my tablet at about 7pm and find I have around 2 hours before I get really sleepy. If I take it later it puts the whole next day out. I am going to try the split dose mentioned above,next time I go out with friends.
    I also suck on sugar free lollies in the evening and morning and it helps with the thirst. I am also convinced the hunger is due to the thirst (for me) and I drink a glass of water before eating anything. It has helped. I was putting on weight b4 this plan and it is now starting to come off again (though slowly). Now I feel more like exercising and am able to so hoping that will also help

  39. 49 Cheryl October 29, 2009 at 1:02 pm

    I am about to start on 10mg Ami and am scared stiff because of my reactions to meds. I suffer from Fibromyalgia and cannot continue with the pain killers and anti inflams. Wondered if I should cut the 10mg in half and start really small.. what you think…..enjoyed reading all the info and candid responses

    • 50 rachelcreative October 30, 2009 at 10:43 am

      I have heard of people doing that in order to adjust to them. But mine are so small I’m not sure I would be able to cut them in half. Maybe crush them and split the powder would work.

      Good luck with it. Hope it helps and you get on with it ok.

    • 51 Vera November 6, 2009 at 12:25 pm

      Cheryl, I’m just like you, My doctor thinks I have Fibromyalgia and percribe 10mg, hate pills, really take good care of myself.
      How are you doing? Not sure if I’ll get the percription filled?

  40. 52 BARRY November 1, 2009 at 12:42 pm

    In 2007 I had to have a total hip replacement but unfortunately the implant became infected and the leg became very painfull.
    I could only sleep between one or two hours a night due to leg pain and constant fidgeting.
    I started to get severe headaches using C0-codamol and the feeling of wanting to be sick using tramadol.
    I was prescribed Amitriptyline 20mg and taken off the other two medications. At first I felt very dopey and off the planet but as my body got more used to them these effects subsided.
    I take two tablets at night and soon fall asleep without pain of fidgeting and get a full nights sleep.I wake with a very dry mouth and black tounge and the taste in my mouth is foul but soon relieved after brushing my teeth.
    Drinking water tastes horrible so I add orange squash or drink flavoured bottled water.I had to have another hip implanted in October and I am still taking Ami.
    At this moment in time I feel much better and able to carry on throughout the day without too much trouble.
    I hope they carry on giving me relief until I am taken off them.


  1. 1 Huh? I’m a Pain Meds Weirdo « ChronicallyMe Trackback on November 8, 2009 at 5:55 pm

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